Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms
and early transcriptional drivers of the vSMC lineage are not well characterized. We find …

… 2 mM, 1 mM MgCl 2 , 1 mM Na 2 HPO 4 , 5 mM N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic …
Focal fatty infiltration of AV node and bundle of His N/A N/A N/A >2M, confirmed ACM on …

A Saskatchewan multi-incident family was clinically characterized with Parkinson disease (PD)
and Lewy body pathology. PD segregates as an autosomal-dominant trait, which could …

Vacuolar protein sorting 35 (VPS35) is a core component of the retromer complex, crucial to
endosomal protein sorting and intracellular trafficking. We recently linked a mutation in …

Mutations in Leucine-Rich Repeat Kinase-2 (LRRK2) result in familial Parkinson's disease
and the G2019S mutation alone accounts for up to 30% in some ethnicities. Despite this, the …

… N = 3 trials, n = 10 cells per trial for each donor–acceptor pair. *P<0.001. Boxes are 1 sd …
N = 3 trials, n = 10 cells per trial for each donor–acceptor pair. *P<0.001. Boxes are 1 sd from …

Mutations in leucine-rich repeat kinase 2 (Lrrk2) are the most common genetic cause of
Parkinson's disease (PD), a neurodegenerative disorder affecting 1–2% of those >65 years old. …

Transglutaminase type 2 (TG2) is a ubiquitously expressed member of the transglutaminase
family, capable of mediating a transamidation reaction between a variety of protein …

Angioblasts of the developing vascular system require many signaling inputs to initiate their
migration, proliferation and differentiation into endothelial cells. What is less studied is which …

To the Editor: Reidl et al. have described the use of a small polypeptide, Lifeact, derived from
yeast, to visualize filamentous actin (f-actin) 1. This reagent, when fused to GFP, allows the …