Polycyclic aromatic hydrocarbons (PAHs) are principally derived from the incomplete combustion
of fossil fuels. This study investigated the occurrence of PAHs in aquatic environments …

Alteration of tryptophan (TRP) metabolism elicited by proinflammatory cytokines has gained
attention as a new concept to explain the etiological and pathophysiological mechanisms of …

Landfill leachate is characterised by high chemical and biological oxygen demand and
generally consists of undesirable substances such as organic and inorganic contaminants. …

The genetic architecture of autism spectrum disorder involves the interplay of common and
rare variants and their impact on hundreds of genes. Using exome sequencing, here we …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date (n
= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

… not identify a single recombinant event within these haplotypes in any of the patients or
control individuals, who were unrelated except for one of the DSPS patients and one of the N‐24 …

Subcortical structures, which include the basal ganglia and parts of the limbic system, have
key roles in learning, motor control and emotion, but also contribute to higher-order executive …

Although cAMP is well known to regulate exocytosis in many secretory cells, its direct target
in the exocytotic machinery is not known. Here we show that cAMP-GEFII, a cAMP sensor, …

Macrophages/monocytes and the proinflammatory mediators, such as tumour necrosis factor
(TNF)-α, prostaglandin E 2 (PGE 2 ), macrophage inflammatory protein (MIP)-1α and MIP-…

Background Lithium is a first-line treatment in bipolar disorder, but individual response is
variable. Previous studies have suggested that lithium response is a heritable trait. However, …