User profiles for N. Paramasivam

Nagarajan Paramasivam

Senior Bioinformatics Scientist, National Center for Tumor Diseases, German Cancer …
Verified email at dkfz.de
Cited by 4462

Essential oil based nanoemulsions to improve the microbial quality of minimally processed fruits and vegetables: A review

A Prakash, R Baskaran, N Paramasivam… - Food Research …, 2018 - Elsevier
Due to the convenience and nutritional value, minimally processed fruits and vegetables (MPFV)
are one of the rapid growing sectors in the food industry. However, their microbiological …

[HTML][HTML] The whole-genome landscape of medulloblastoma subtypes

…, N Jäger, L Chavez, B Hutter, M Bieg, N Paramasivam… - Nature, 2017 - nature.com
… Restricting our analysis to Group 3 and Group 4 (n = 740) separated the parental subgroups
into up to eight subtypes (Fig. 4a, b). Iterative down-sampling performed on the same …

[HTML][HTML] A comprehensive assessment of somatic mutation detection in cancer using whole-genome sequencing

…, P Ginsbach, R Drews, N Paramasivam… - Nature …, 2015 - nature.com
As whole-genome sequencing for cancer genome analysis becomes a clinical tool, a full
understanding of the variables affecting sequencing analysis output is required. Here using …

[HTML][HTML] The genomic and transcriptional landscape of primary central nervous system lymphoma

…, D Juraeva, F Pritsch, N Paramasivam… - Nature …, 2022 - nature.com
… Whole-genome sequencing data were obtained from n = 38 PCNSL/SCNSL patients.
RNA sequencing data was generated from n = 37 PCNSL/SCNSL patients and n = 2 normal …

[PDF][PDF] De novo mutations in protein kinase genes CAMK2A and CAMK2B cause intellectual disability

…, U Moog, K Hinderhofer, N Paramasivam… - The American Journal of …, 2017 - cell.com
Calcium/calmodulin-dependent protein kinase II (CAMK2) is one of the first proteins shown
to be essential for normal learning and synaptic plasticity in mice, but its requirement for …

Efficient subfractionation of gram-negative bacteria for proteomics studies

M Thein, G Sauer, N Paramasivam, I Grin… - Journal of proteome …, 2010 - ACS Publications
… Intensity threshold for AutoMS(n) detection was set to 5000 and up to 3000 fragmentation
spectra were allowed. Deconvolution parameters were set to auto for MS and MS/MS data. …

[HTML][HTML] Whole genome sequencing puts forward hypotheses on metastasis evolution and therapy in colorectal cancer

…, ML Abba, C Hauser, N Patil, N Paramasivam… - Nature …, 2018 - nature.com
Incomplete understanding of the metastatic process hinders personalized therapy. Here we
report the most comprehensive whole-genome study of colorectal metastases vs. matched …

[HTML][HTML] Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

…, Z Huang, L Sieverling, N Paramasivam… - Nature …, 2019 - nature.com
… = 2) with mBL signature and B-cell lymphoma not otherwise specified (B-NOS, n = 1) from
the ICGC MMML-Seq project (unpublished data). In this extended cohort we observed a …

[HTML][HTML] Mutational mechanisms shaping the coding and noncoding genome of germinal center derived B-cell lymphomas

…, H Kretzmer, M Kreuz, SM Waszak, N Paramasivam… - Leukemia, 2021 - nature.com
… = 2,323, 51.2%), one with predominant contributions of CSR (n = 428, 9.4%) and one with
low contributions of SHM and CSR (n = 1,787, 39.4%). This classification persisted when …

[HTML][HTML] Comprehensive genomic and epigenomic analysis in cancer of unknown primary guides molecularly-informed therapies despite heterogeneity

…, M Fröhlich, B Hutter, N Paramasivam… - Nature …, 2022 - nature.com
… In four cases the FGFR2 fusion was intrachromosomal and included inversions (n = 3,
twice with BICC1), translocations (n = 2) and a deletion (n = 1). All samples tested for …