[HTML][HTML] SAR and identification of 2-(quinolin-4-yloxy) acetamides as Mycobacterium tuberculosis cytochrome bc 1 inhibitors
N Phummarin, HI Boshoff, PS Tsang, J Dalton… - …, 2016 - pubs.rsc.org
A previous phenotypic screen by GSK identified 2-(quinolin-4-yloxy)acetamides as potent
growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary …
growth inhibitors of Mycobacterium tuberculosis (Mtb). We report the results of a preliminary …
[HTML][HTML] Effect of common and experimental anti-tuberculosis treatments on Mycobacterium tuberculosis growing as biofilms
Much is known regarding the antibiotic susceptibility of planktonic cultures of Mycobacterium
tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB). As …
tuberculosis, the bacterium responsible for the lung disease tuberculosis (TB). As …
Synthesis and Reactivity of 1, 4-Dicarbonyl Compounds Related to the Natural Product Onchidal
N Phummarin - 2017 - researchspace.auckland.ac.nz
Onchidal is the secondary metabolite produced by the opisthobranch mollusc Onchidella
binneyi. The sesquiterpene acetate natural product possesses the ability to irreversibly bind to, …
binneyi. The sesquiterpene acetate natural product possesses the ability to irreversibly bind to, …
Targeting the cytochrome oxidases for drug development in mycobacteria
Mycobacterium tuberculosis strictly depends on oxygen to multiply, and the terminal oxidases
are a vital part of the oxidative phosphorylation pathway. The bacterium possesses two …
are a vital part of the oxidative phosphorylation pathway. The bacterium possesses two …
Reply to Yew et al.,“Vitamin C and Mycobacterium tuberculosis Persisters”
C Vilchèze, WR Jacobs Jr - Antimicrobial agents and …, 2018 - Am Soc Microbiol
We thank Yew and coauthors (1) for their interest in our article (2) and for highlighting the
complexity of the activity of vitamin C on mycobacteria grown in vitro. The cited studies reached …
complexity of the activity of vitamin C on mycobacteria grown in vitro. The cited studies reached …
No Evidence for Acquired Mutations Associated with Cytochrome bc1 Inhibitor Resistance in 13,559 Clinical Mycobacterium tuberculosis Complex Isolates
J Rybniker, TA Kohl, I Barilar… - Antimicrobial Agents and …, 2019 - Am Soc Microbiol
No Evidence for Acquired Mutations Associated with Cytochrome bc1 Inhibitor Resistance
in 13,559 Clinical Mycobacterium tuberculosis Complex Isolates | Antimicrobial Agents and …
in 13,559 Clinical Mycobacterium tuberculosis Complex Isolates | Antimicrobial Agents and …
[HTML][HTML] Activity of 2-(quinolin-4-yloxy) acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome …
The 2-(quinolin-4-yloxy)acetamides (QOAs) have been reported to be promising molecules
for tuberculosis treatment. Recent studies demonstrated their potent antimycobacterial activity…
for tuberculosis treatment. Recent studies demonstrated their potent antimycobacterial activity…
Mycobacterial membrane proteins QcrB and AtpE: roles in energetics, antibiotic targets, and associated mechanisms of resistance
L Bown, SK Srivastava, BM Piercey… - The Journal of …, 2018 - Springer
Infections caused by mycobacteria are difficult to treat due to their inherent physiology, cellular
structure, and intracellular lifestyle. Mycobacterium tuberculosis is a pathogen of global …
structure, and intracellular lifestyle. Mycobacterium tuberculosis is a pathogen of global …
[HTML][HTML] Validity and reliability of a Thai version of the Body Image Scale among patients with post-coronary artery bypass graft
P Moonkaew, R Polsook - Belitung Nursing Journal, 2023 - ncbi.nlm.nih.gov
Background Body image is a significant concern for patients who have undergone a coronary
artery bypass graft (CABG) surgery, as the presence of scars on the chest, arms, and legs …
artery bypass graft (CABG) surgery, as the presence of scars on the chest, arms, and legs …
Arylvinylpiperazine amides, a new class of potent inhibitors targeting QcrB of Mycobacterium tuberculosis
New drugs are needed to control the current tuberculosis (TB) pandemic caused by
infection with Mycobacterium tuberculosis . We report here on our work with AX-35, an …
infection with Mycobacterium tuberculosis . We report here on our work with AX-35, an …