Abnormal vascular smooth muscle cell (VSMC) contraction plays an important role in vascular
diseases. The RhoA/ROCK signaling pathway is now well recognized to mediate vascular …

Animal models have provided valuable information related to trait and state variables
associated with vulnerability to drug addiction. Our brain imaging studies in monkeys have …

Naturally simian immunodeficiency virus (SIV)-infected sooty mangabeys do not progress to
AIDS despite high-level virus replication. We previously showed that the fraction of CD4 + …

Angelman syndrome (AS) is a severe neurodevelopmental disorder associated with disruption
of maternally inherited UBE3A (ubiquitin protein ligase E3A) expression. At the present …

… f Co-IP assay assessing HDAC6 binding to tau isoforms varying in the number of N-terminal
inserts (0N, 1N, or 2N) or MTBR domains (3R or 4R). 3R-tau (0N3R, 1N3R, and 2N3R) and …

… Subjects were tested for sociability 24 h following the final dose (N = 16 per sex, per treatment).
Half of the mice were further tested 1 week (1 wk) after the sub-chronic oxytocin regimen, …

… Samples (250 μl) were extracted with 2.5 ml of anesthesia-grade ether and the organic layer
was evaporated to dryness under a stream of N 2 . The sample was reconstituted in 250 μl …

… that were naturally infected (n = 120) and those with documented SIV-negative status (n =
72), and excluded animals in the colony known to have been experimentally infected (n = 10). …

… METHODS: DA D2/D3 receptor availability was assessed in female cynomolgus monkeys
(n = 16) with positron emission tomography (PET) while they were individually housed, 3 …

Increased mortality in antiretroviral (ARV)-treated, HIV-infected individuals has been
attributed to persistent immune dysfunction, in part due to abnormalities at the gastrointestinal …