Chromosome 17q12-21 remains the most highly replicated and significant asthma locus.
Genotypes in the core region defined by the first genome-wide association study correlate with …

This review focuses on recent clinical and translational discoveries in severe and uncontrolled
asthma that now enable phenotyping and personalized therapies in these patients. …

This review focuses on genome-wide association studies (GWASs) of asthma and allergic
diseases published between January 1, 2018, and June 30, 2019. During this time period, …

… with asthma in the UK Biobank who met our inclusion criteria (n=37 846), including those
with onset during adolescence or young adulthood (n=6849). In this analysis, 19 loci were …

… Naive rats (n = 4) were not immunized and did not receive drug treatment. … The
reaction was stopped with 50 μl of 1 N sulfuric acid and the plates were read at 450 nm. …

Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million
people worldwide, with increasing incidence in westernized countries 1 , 2 . To elucidate the …

… The numbers of GSDMB + bronchial epithelial cells were higher in asthmatics (n = 14)
compared with control subjects (n = 7) and were highest in subjects with severe asthma (…

Autopsies of patients who have died from COVID‐19 have been crucial in delineating
patterns of injury associated with SARS‐CoV‐2 infection. Despite their utility, comprehensive …

… The most significant association in our GWAS was with SNPs (N = 96, smallest p = 4.45 ×
10 −9 ) on 17q12-21, including ZPBP2, GSDMB, IKZF, and ORMDL3. Chromosome 17q12-21 …

… up to the latest age of study participation (n=318,167). Individuals with chronic obstructive …
COA (n=1686), AOA (n=3666), and non-asthmatic controls in the replication cohort (n=56,063)…