… Part 2 consisted of testing for bioequivalence between the oral tablet form and the oral
suspension form, which was not included in this analysis (n = 11). Part 3 consisted of daily dosing …

Global antimalaria scale-up has significantly decreased malaria morbidity and mortality in
many regions of the world. However, countries with the highest Plasmodium falciparum …

… Delayed-onset neutropenia (n = 8) and increased liver enzymes (n = 8) were found in
fexinidazole patients vs none in the placebo arm. In the ITT analysis, sustained parasitological …

After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human
African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of …

Vertical transmission of Trypanosoma cruzi is the cause of congenital Chagas disease, a re-emerging
infectious disease that affects endemic and nonendemic regions alike. An early …

After 100 years of chemotherapy with impractical and toxic drugs, an oral cure for human
African trypanosomiasis (HAT) is available: Fexinidazole. In this case, we review the history of …

Full article: In-silico identification of fingerprint of pyrazolyl sulfonamide responsible for inhibition
of N-myristoyltransferase using Monte Carlo method with index of ideality of correlation …

Chagas disease (CD) is a tropical neglected illness, affecting mainly populations of low
socioeconomic status in Latin America. An estimated 6 to 8 million people worldwide are …

Phenotypic screening of a 900 compound library of antitubercular nitroimidazole derivatives
related to pretomanid against the protozoan parasite Trypanosoma cruzi (the causative …

Chagas disease caused by the protozoan Trypanosoma cruzi is endemic to 21 countries in
the Americas, effects approximately 6 million people and on average results in 12,000 …