Complex paths around the sign problem
… methods that we discuss in this review sample an N-dimensional manifold. Results show
that, … over N cycles, orientable manifolds with no boundary with real dimension N immersed in …
that, … over N cycles, orientable manifolds with no boundary with real dimension N immersed in …
Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function
…, V Vitart, H Voelzke, NJ Wareham, NM Warrington… - Nature …, 2011 - nature.com
Pulmonary function measures reflect respiratory health and are used in the diagnosis of
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
chronic obstructive pulmonary disease. We tested genome-wide association with forced …
Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
…, C Williams, J Hui, J Beilby, NM Warrington… - Nature …, 2009 - nature.com
Eosinophils are pleiotropic multifunctional leukocytes involved in initiation and propagation
of inflammatory responses and thus have important roles in the pathogenesis of …
of inflammatory responses and thus have important roles in the pathogenesis of …
LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and …
…, BS Pourcain, NM Warrington… - …, 2017 - academic.oup.com
Motivation LD score regression is a reliable and efficient method of using genome-wide
association study (GWAS) summary-level results data to estimate the SNP heritability of complex …
association study (GWAS) summary-level results data to estimate the SNP heritability of complex …
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies
To identify loci for age at menarche, we performed a meta-analysis of 32 genome-wide
association studies in 87,802 women of European descent, with replication in up to 14,731 …
association studies in 87,802 women of European descent, with replication in up to 14,731 …
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Birth weight variation is influenced by fetal and maternal genetic and non-genetic factors,
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
and has been reproducibly associated with future cardio-metabolic health outcomes. In …
Genome-wide associations for birth weight and correlations with adult disease
Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in
observational studies is reproducibly associated with future risk of adult metabolic diseases …
observational studies is reproducibly associated with future risk of adult metabolic diseases …
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
…, C Medina-Gomez, V Forgetta, NM Warrington… - Nature …, 2017 - nature.com
Osteoporosis is a common disease diagnosed primarily by measurement of bone mineral
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
density (BMD). We undertook a genome-wide association study (GWAS) in 142,487 …
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis
Atopic dermatitis (AD) is a commonly occurring chronic skin disease with high heritability.
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …
Apart from filaggrin (FLG), the genes influencing atopic dermatitis are largely unknown. We …
Brief report: intestinal dysbiosis in ankylosing spondylitis
…, F Ciccia, D Willner, N Warrington… - Arthritis & …, 2015 - Wiley Online Library
Objective Ankylosing spondylitis (AS) is a common, highly heritable immune‐mediated
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely …
arthropathy that occurs in genetically susceptible individuals exposed to an unknown but likely …