We report a new Streptomyces species named S. formicae that was isolated from the African
fungus-growing plant-ant Tetraponera penzigi and show that it produces novel pentacyclic …

Transmission of trypanosomatids to their mammalian hosts requires a complex series of
developmental transitions in their insect vectors, including stable attachment to an insect tissue. …

Polarized growth in eukaryotes requires polar multiprotein complexes. Here, we establish
that selection and maintenance of cell polarity for growth also requires a dedicated …

Streptomyces bacteria are ubiquitous in soils and are well known for producing secondary
metabolites, including antimicrobials. Increasingly, they are being isolated from plant roots, …

Studies of transcriptional initiation in different bacterial clades reveal diverse molecular
mechanisms regulating this first step in gene expression. The WhiA and WhiB factors are both …

Acromyrmex leafcutter ants form a mutually beneficial symbiosis with the fungus Leucoagaricus
gongylophorus and with Pseudonocardia bacteria. Both are vertically transmitted and …

Streptomyces are our primary source of antibiotics, produced concomitantly with the transition
from vegetative growth to sporulation in a complex developmental life cycle. We previously …

The attine ants of South and Central America are ancient farmers, having evolved a symbiosis
with a fungal food crop >50 million years ago. The most evolutionarily derived attines are …

Introduction Mental health interventions disseminated via, or accessed using, digital
technologies are an innovative new treatment modality for managing co-morbid depression and …

Antimicrobial resistance (AMR) is a growing societal problem, and without new antiinfective
drugs, the UK government-commissioned O’Neil report has predicted that infectious disease …