Proproteins and prohormones are the fundamental units from which bioactive proteins and
peptides as well as neuropeptides are derived by limited proteolysis within the secretory …

The mammalian proprotein convertases constitute a family of nine secretory serine
proteases that are related to bacterial subtilisin and yeast kexin. Seven of these (proprotein …

Since the discovery of proprotein convertase subtilisin kexin 9 (PCSK9) in 2003, this PC has
attracted a lot of attention from the scientific community and pharmaceutical companies. …

Autosomal dominant hypercholesterolemia (ADH; OMIM144400), a risk factor for coronary
heart disease, is characterized by an increase in low-density lipoprotein cholesterol levels …

Background Severe acute respiratory syndrome (SARS) is caused by a newly discovered
coronavirus (SARS-CoV). No effective prophylactic or post-exposure therapy is currently …

In 2019, a new coronavirus (2019-nCoV) infecting Humans has emerged in Wuhan, China.
Its genome has been sequenced and the genomic information promptly released. Despite a …

Seven secretory mammalian kexin-like subtilases have been identified that cleave a variety
of precursor proteins at monobasic and dibasic residues. The recently characterized …

The Notch receptor, which is involved in numerous cell fate decisions in invertebrates and
vertebrates, is synthesized as a 300-kDa precursor molecule (p300). We show here that …

The clinical efficacy and safety of a drug is determined by its activity profile across many
proteins in the proteome. However, designing drugs with a specific multi-target profile is both …

Objective— Neural apoptosis-regulated convertase (NARC)-1 is the newest member of the
proprotein convertase family implicated in the cleavage of a variety of protein precursors. The …