Pancreatic β cell failure leads to diabetes development. During disease progression, β cells
adapt their secretory capacity to compensate the elevated glycaemia and the peripheral …

We have discovered and developed a series of molecules (thiazole benzenesulfonamides).
HA15, the lead compound of this series, displayed anti-cancerous activity on all melanoma …

Innate immune responses are intricately linked with intracellular metabolism of myeloid cells.
Toll-like receptor (TLR) stimulation shifts intracellular metabolism toward glycolysis, while …

Obesity and metabolic diseases, such as insulin resistance and type 2 diabetes (T2D), are
associated with metastatic breast cancer in postmenopausal women. Here, we investigated …

Adipose tissue fibrosis is regulated by the chronic and progressive metabolic imbalance
caused by differences in caloric intake and energy expenditure. By exploring the cellular …

Visceral white adipose tissue (vWAT) expands and undergoes extensive remodeling during
diet-induced obesity. Much is known about the contribution of various stromal vascular cells …

Chromatin architectures and epigenetic fingerprint regulation are fundamental for genetically
determined biological processes. Chemical modifications of the chromatin template …

Type 2 diabetes is characterized by chronic hyperglycemia associated with impaired insulin
action and secretion. Although the heritability of type 2 diabetes is high, the environment, …

The ARF/INK4A (Cdkn2a) locus includes the linked tumour suppressor genes p16INK4a
and p14ARF (p19ARF in mice) that trigger the antiproliferative activities of both RB and p53. …

Objectives Genome-wide association studies have reported that DNA polymorphisms at the
CDKN2A locus modulate fasting glucose in human and contribute to type 2 diabetes (T2D) …