In prokaryotes and eukaryotes, most genes appear to be transcribed during short periods
called transcriptional bursts, interspersed by silent intervals. We describe how such bursts …

Immune cells provide defense against non‐self and have recently been shown to also play
key roles in diverse processes such as development, metabolism, and tumor progression. …

… ,5 Vladimir Benes,4 Nacho Molina,6 and Arnaud Regis Krebs1… Work in the lab of Nacho
Molina is supported by the grant ANR-10-LABX-0030-INRT. Nacho Molina is supported by a …

SwissRegulon ( ) is a database containing genome-wide annotations of regulatory sites in
the intergenic regions of genomes. The regulatory site annotations are produced using a …

For high-level functional categories that are represented in almost all prokaryotic genomes,
the numbers of genes in these categories scale as power-laws in the total number of genes. …

Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) experiments are
widely used to determine, within entire genomes, the occupancy sites of any protein of interest…

Mammalian genes are often transcribed discontinuously as short bursts of RNA synthesis
followed by longer silent periods. However, how these “on” and “off” transitions, together with …

Mammalian transcription occurs stochastically in short bursts interspersed by silent intervals
showing a refractory period. However, the underlying processes and consequences on …

The transcription factors BMAL1 and CLOCK drive the circadian transcription of clock and
clock-controlled genes, such as Dbp. To investigate the kinetics of BMAL1 binding to target …

Motivation: Probabilistic approaches for inferring transcription factor binding sites (TFBSs)
and regulatory motifs from DNA sequences have been developed for over two decades. …