[PDF][PDF] Neuron-specific protein network mapping of autism risk genes identifies shared biological mechanisms and disease-relevant pathologies

N Murtaza, AA Cheng, CO Brown, DP Meka, S Hong… - Cell Reports, 2022 - cell.com
There are hundreds of risk genes associated with autism spectrum disorder (ASD), but
signaling networks at the protein level remain unexplored. We use neuron-specific proximity-…

[HTML][HTML] Emerging proteomic approaches to identify the underlying pathophysiology of neurodevelopmental and neurodegenerative disorders

N Murtaza, J Uy, KK Singh - Molecular Autism, 2020 - Springer
Proteomics is the large-scale study of the total protein content and their overall function
within a cell through multiple facets of research. Advancements in proteomic methods have …

[HTML][HTML] Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling

M Richter, N Murtaza, R Scharrenberg, SH White… - Molecular …, 2019 - nature.com
Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental
disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several …

[PDF][PDF] OTUD7A regulates neurodevelopmental phenotypes in the 15q13. 3 microdeletion syndrome

…, KS Ho, E Harward, N Murtaza… - The American Journal of …, 2018 - cell.com
Copy-number variations (CNVs) are strong risk factors for neurodevelopmental and psychiatric
disorders. The 15q13.3 microdeletion syndrome region contains up to ten genes and is …

[HTML][HTML] CD70 as an actionable immunotherapeutic target in recurrent glioblastoma and its microenvironment

…, W Gwynne, K Brown, N Murtaza… - … for immunotherapy of …, 2022 - ncbi.nlm.nih.gov
Purpose Glioblastoma (GBM) patients suffer from a dismal prognosis, with standard of care
therapy inevitably leading to therapy-resistant recurrent tumors. The presence of cancer stem …

[HTML][HTML] TAOK2 rescues autism-linked developmental deficits in a 16p11. 2 microdeletion mouse model

…, O Johanns, DP Meka, T Rücker, N Murtaza… - Molecular …, 2022 - nature.com
The precise development of the neocortex is a prerequisite for higher cognitive and associative
functions. Despite numerous advances that have been made in understanding neuronal …

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation

…, N Neelagandan, D Daaboul, N Murtaza… - Science …, 2024 - science.org
Genes implicated in translation control have been associated with autism spectrum
disorders (ASDs). However, some important genetic causes of autism, including the 16p11.2 …

[PDF][PDF] DIXDC1 phosphorylation and control of dendritic morphology are impaired by rare genetic variants

…, CL Hung, NT Holzapfel, S Walker, N Murtaza… - Cell reports, 2016 - cell.com
The development of neural connectivity is essential for brain function, and disruption of this
process is associated with autism spectrum disorders (ASDs). DIX domain containing 1 (…

[HTML][HTML] Impaired OTUD7A-dependent Ankyrin regulation mediates neuronal dysfunction in mouse and human models of the 15q13. 3 microdeletion syndrome

…, S Yoon, S Kilpatrick, C Irwin, S Xing, N Murtaza… - Molecular …, 2023 - nature.com
Copy number variations (CNVs) are associated with psychiatric and neurodevelopmental
disorders (NDDs), and most, including the recurrent 15q13.3 microdeletion disorder, have …

[HTML][HTML] Impact of Limosilactobacillus fermentum probiotic treatment on gut microbiota composition in sahiwal calves with rotavirus diarrhea: A 16S metagenomic …

N Murtaza, M Nawaz, T Yaqub, AK Mehmood - BMC microbiology, 2024 - Springer
Diarrhea poses a major threat to bovine calves leading to mortality and economic losses.
Among the causes of calf diarrhea, bovine rotavirus is a major etiological agent and may result …