Bcr/Abl is a chimeric oncogene that can cause both acute and chronic human leukemias.
Bcr/Abl-encoded proteins exhibit elevated kinase activity compared to c-Abl, but the …

Hematopoietic stem cells sequentially pass through a series of decision points affecting self-renewal
or lineage-specific differentiation. Notch1 receptor is a known modulator of lineage-…

The ability to track the distribution and differentiation of progenitor and stem cells by high-resolution
in vivo imaging techniques would have significant clinical and research implications. …

Beige adipocytes in white adipose tissue (WAT) are similar to classical brown adipocytes in
that they can burn lipids to produce heat. Thus, an increase in beige adipocyte content in …

Hematopoiesis is a balance between proliferation and differentiation that may be modulated
by environmental signals. Notch receptors and their ligands are highly conserved during …

Myelodysplastic syndrome (MDS), a largely incurable hematological malignancy, is derived
from aberrant clonal hematopoietic stem/progenitor cells (HSPCs) that persist after …

Osteocytes, >90% of the cells in bone, lie embedded within the mineralized matrix and
coordinate osteoclast and osteoblast activity on bone surfaces by mechanisms still unclear. Bone …

Background— Activated macrophages contribute to the pathogenesis of inflammatory
diseases such as atherosclerosis. Although Notch signaling participates in various aspects of …

The microRNA miR-155 has been implicated in regulating inflammatory responses and
tumorigenesis, but its precise role in linking inflammation and cancer has remained elusive. Here…

In multiple myeloma, an overabundance of monoclonal plasma cells in the bone marrow
induces localized osteolytic lesions that rarely heal due to increased bone resorption and …