Proper organization of microtubule arrays is essential for intracellular trafficking and cell
motility. It is generally assumed that most if not all microtubules in vertebrate somatic cells are …

Microtubules are indispensable for Golgi complex assembly and maintenance, which are
integral parts of cytoplasm organization during interphase in mammalian cells. Here, we show …

Adherens junctions (AJs) are mechanosensitive cadherin-based intercellular adhesions
that interact with the actin cytoskeleton and carry most of the mechanical load at cell–cell …

The formation and recovery of gaps in the vascular endothelium governs a wide range of
physiological and pathological phenomena, from angiogenesis to tumor cell extravasation. …

Dendritic spines are postsynaptic structures in neurons often having a mushroom-like shape.
Physiological significance and cytoskeletal mechanisms that maintain this shape are …

Cell migration is driven by pushing and pulling activities of the actin cytoskeleton, but
migration directionality is largely controlled by microtubules. This function of microtubules is …

Actin polymerization is a universal mechanism to drive plasma membrane protrusion in motile
cells. One apparent exception to this rule is continuing or even accelerated outgrowth of …

Coordination between the microtubule and actin networks is essential for cell motility, neuronal
growth cone guidance, and wound healing. Members of the CLASP (cytoplasmic linker-…

The kinesin KIF1C is known to regulate podosomes, actin-rich adhesion structures that
remodel the extracellular matrix during physiological processes. Here, we show that KIF1C is a …

Transendothelial cell macroaperture (TEM) tunnels control endothelium barrier function and
are triggered by several toxins from pathogenic bacteria that provoke vascular leakage. …