In the adult central nervous system, the vasculature of the neurogenic niche regulates neural
stem cell behavior by providing circulating and secreted factors. Age-related decline of …

Background Restless legs syndrome is a prevalent chronic neurological disorder with
potentially severe mental and physical health consequences. Clearer understanding of the …

Background Attention-deficit/hyperactivity disorder (ADHD) shows substantial heritability
and is two to seven times more common in male individuals than in female individuals. We …

Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the
excessive production of mature myeloid cells and arise from the acquisition of somatic driver …

Complex traits, including migraine, often aggregate in families, but the underlying genetic
architecture behind this is not well understood. The aggregation could be explained by rare, …

Protein tyrosine nitration has been observed in a variety of human diseases associated with
oxidative stress, such as inflammatory, neurodegenerative, and cardiovascular conditions. …

Meiotic nondisjunction and resulting aneuploidy can lead to severe health consequences in
humans. Aneuploidy rescue can restore euploidy but may result in uniparental disomy (UPD…

The mechanism underlying selective motor neuron (MN) death remains an essential question
in the MN disease field. The MN disease spinal muscular atrophy (SMA) is attributable to …

The timing of puberty is highly variable and is associated with long-term health outcomes.
To date, understanding of the genetic control of puberty timing is based largely on studies in …

Hypersensitivity reactions to drugs are often unpredictable and can be life threatening,
underscoring a need for understanding their underlying mechanisms and risk factors. The extent …