We have sequenced the genomes of 110 small cell lung cancers (SCLC), one of the deadliest
human cancers. In nearly all the tumours analysed we found bi-allelic inactivation of TP53 …

Small-cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer with limited
treatment options. CD47 is a cell-surface molecule that promotes immune evasion by engaging …

Small cell lung cancer (SCLC) is an aggressive neuroendocrine subtype of lung cancer with
high mortality. We used a systematic drug repositioning bioinformatics approach querying a …

The Notch signalling pathway mediates cell fate decisions 1 , 2 and is tumour suppressive
or oncogenic depending on the context 2 , 3 . During lung development, Notch pathway …

The general transcription factor P-TEFb stimulates RNA polymerase II elongation and
cotranscriptional processing of pre-mRNA. Contributing to a functional equilibrium important for …

Converting checkpoint inhibitor (CPI)-resistant individuals to being responsive requires
identifying suppressive mechanisms. We identify TREM2 + tumor-associated macrophages (…

The extent to which early events shape tumor evolution is largely uncharacterized, even
though a better understanding of these early events may help identify key vulnerabilities in …

The tumor microenvironment (TME) of diverse cancer types is often characterized by high
levels of infiltrating myeloid cells including monocytes, macrophages, dendritic cells, and …

Activity of the serine-threonine protein kinase PINOID (PID) has been implicated in the
asymmetrical localization of the membrane-associated PINFORMED (PIN) family of auxin …

Pancreatic neuroendocrine tumors (PanNETs) are a type of pancreatic cancer with limited
therapeutic options. Consequently, most patients with advanced disease die from tumor …