User profiles for Nadine Töpfer
Nadine TöpferInstitute for Plant Sciences at University of Cologne Verified email at uni-koeln.de Cited by 639 |
[HTML][HTML] Metabolite profiling and integrative modeling reveal metabolic constraints for carbon partitioning under nitrogen starvation in the green algae Haematococcus …
L Recht, N Töpfer, A Batushansky, N Sikron… - Journal of Biological …, 2014 - ASBMB
The green alga Hematococcus pluvialis accumulates large amounts of the antioxidant
astaxanthin under inductive stress conditions, such as nitrogen starvation. The response to …
astaxanthin under inductive stress conditions, such as nitrogen starvation. The response to …
[HTML][HTML] Integration of metabolomics data into metabolic networks
N Töpfer, S Kleessen, Z Nikoloski - Frontiers in plant science, 2015 - frontiersin.org
Metabolite levels together with their corresponding metabolic fluxes are integrative
outcomes of biochemical transformations and regulatory processes and they can be used to …
outcomes of biochemical transformations and regulatory processes and they can be used to …
The PhytoClust tool for metabolic gene clusters discovery in plant genomes
The existence of Metabolic Gene Clusters (MGCs) in plant genomes has recently raised
increased interest. Thus far, MGCs were commonly identified for pathways of specialized …
increased interest. Thus far, MGCs were commonly identified for pathways of specialized …
Alternative crassulacean acid metabolism modes provide environment-specific water-saving benefits in a leaf metabolic model
Crassulacean acid metabolism (CAM) evolved in arid environments as a water-saving
alternative to C 3 photosynthesis. There is great interest in engineering more drought-resistant …
alternative to C 3 photosynthesis. There is great interest in engineering more drought-resistant …
Label‐free deep shotgun proteomics reveals protein dynamics during tomato fruit tissues development
…, L Chappell‐Maor, U Heinig, N Töpfer… - The Plant …, 2017 - Wiley Online Library
Current innovations in mass‐spectrometry‐based technologies allow deep coverage of protein
expression. Despite its immense value and in contrast to transcriptomics, only a handful …
expression. Despite its immense value and in contrast to transcriptomics, only a handful …
[HTML][HTML] Advances in flux balance analysis by integrating machine learning and mechanism-based models
The availability of multi-omics data sets and genome-scale metabolic models for various
organisms provide a platform for modeling and analyzing genotype-to-phenotype relationships. …
organisms provide a platform for modeling and analyzing genotype-to-phenotype relationships. …
Integration of Genome-Scale Modeling and Transcript Profiling Reveals Metabolic Pathways Underlying Light and Temperature Acclimation in Arabidopsis
N Töpfer, C Caldana, S Grimbs, L Willmitzer… - The plant …, 2013 - academic.oup.com
Understanding metabolic acclimation of plants to challenging environmental conditions is
essential for dissecting the role of metabolic pathways in growth and survival. As stresses …
essential for dissecting the role of metabolic pathways in growth and survival. As stresses …
iReMet-flux: constraint-based approach for integrating relative metabolite levels into a stoichiometric metabolic models
M Sajitz-Hermstein, N Töpfer, S Kleessen… - …, 2016 - academic.oup.com
Motivation Understanding the rerouting of metabolic reaction fluxes upon perturbations has
the potential to link changes in molecular state of a cellular system to alteration of growth. Yet…
the potential to link changes in molecular state of a cellular system to alteration of growth. Yet…
[HTML][HTML] Integration of time-resolved transcriptomics data with flux-based methods reveals stress-induced metabolic adaptation in Escherichia coli
N Töpfer, S Jozefczuk, Z Nikoloski - BMC Systems Biology, 2012 - Springer
Background Changes in environmental conditions require temporal effectuation of different
metabolic pathways in order to maintain the organisms’ viability but also to enable the …
metabolic pathways in order to maintain the organisms’ viability but also to enable the …
Integration of plant metabolomics data with metabolic networks: progresses and challenges
In the last decade, plant genome-scale modeling has developed rapidly and modeling
efforts have advanced from representing metabolic behavior of plant heterotrophic cell …
efforts have advanced from representing metabolic behavior of plant heterotrophic cell …