User profiles for Nadine Töpfer

Nadine Töpfer

Institute for Plant Sciences at University of Cologne
Verified email at uni-koeln.de
Cited by 639

[HTML][HTML] Metabolite profiling and integrative modeling reveal metabolic constraints for carbon partitioning under nitrogen starvation in the green algae Haematococcus …

L Recht, N Töpfer, A Batushansky, N Sikron… - Journal of Biological …, 2014 - ASBMB
The green alga Hematococcus pluvialis accumulates large amounts of the antioxidant
astaxanthin under inductive stress conditions, such as nitrogen starvation. The response to …

[HTML][HTML] Integration of metabolomics data into metabolic networks

N Töpfer, S Kleessen, Z Nikoloski - Frontiers in plant science, 2015 - frontiersin.org
Metabolite levels together with their corresponding metabolic fluxes are integrative
outcomes of biochemical transformations and regulatory processes and they can be used to …

The PhytoClust tool for metabolic gene clusters discovery in plant genomes

N Töpfer, LM Fuchs, A Aharoni - Nucleic Acids Research, 2017 - academic.oup.com
The existence of Metabolic Gene Clusters (MGCs) in plant genomes has recently raised
increased interest. Thus far, MGCs were commonly identified for pathways of specialized …

Alternative crassulacean acid metabolism modes provide environment-specific water-saving benefits in a leaf metabolic model

N Töpfer, T Braam, S Shameer, RG Ratcliffe… - The Plant …, 2020 - academic.oup.com
Crassulacean acid metabolism (CAM) evolved in arid environments as a water-saving
alternative to C 3 photosynthesis. There is great interest in engineering more drought-resistant …

Label‐free deep shotgun proteomics reveals protein dynamics during tomato fruit tissues development

…, L Chappell‐Maor, U Heinig, N Töpfer… - The Plant …, 2017 - Wiley Online Library
Current innovations in mass‐spectrometry‐based technologies allow deep coverage of protein
expression. Despite its immense value and in contrast to transcriptomics, only a handful …

[HTML][HTML] Advances in flux balance analysis by integrating machine learning and mechanism-based models

A Sahu, MA Blätke, JJ Szymański, N Töpfer - Computational and Structural …, 2021 - Elsevier
The availability of multi-omics data sets and genome-scale metabolic models for various
organisms provide a platform for modeling and analyzing genotype-to-phenotype relationships. …

Integration of Genome-Scale Modeling and Transcript Profiling Reveals Metabolic Pathways Underlying Light and Temperature Acclimation in Arabidopsis

N Töpfer, C Caldana, S Grimbs, L Willmitzer… - The plant …, 2013 - academic.oup.com
Understanding metabolic acclimation of plants to challenging environmental conditions is
essential for dissecting the role of metabolic pathways in growth and survival. As stresses …

iReMet-flux: constraint-based approach for integrating relative metabolite levels into a stoichiometric metabolic models

M Sajitz-Hermstein, N Töpfer, S Kleessen… - …, 2016 - academic.oup.com
Motivation Understanding the rerouting of metabolic reaction fluxes upon perturbations has
the potential to link changes in molecular state of a cellular system to alteration of growth. Yet…

[HTML][HTML] Integration of time-resolved transcriptomics data with flux-based methods reveals stress-induced metabolic adaptation in Escherichia coli

N Töpfer, S Jozefczuk, Z Nikoloski - BMC Systems Biology, 2012 - Springer
Background Changes in environmental conditions require temporal effectuation of different
metabolic pathways in order to maintain the organisms’ viability but also to enable the …

Integration of plant metabolomics data with metabolic networks: progresses and challenges

N Töpfer, SMD Seaver, A Aharoni - Plant Metabolomics: Methods and …, 2018 - Springer
In the last decade, plant genome-scale modeling has developed rapidly and modeling
efforts have advanced from representing metabolic behavior of plant heterotrophic cell …