User profiles for Nadira Yuldasheva

Nadira Yusupovna Yuldasheva

Head of Experimental Cardiovascular Surgery, University of Leeds
Cited by 16541

Piezo1 integration of vascular architecture with physiological force

…, AJ Hyman, L McKeown, RS Young, NY Yuldasheva… - Nature, 2014 - nature.com
The mechanisms by which physical forces regulate endothelial cells to determine the
complexities of vascular structure and function are enigmatic 1 , 2 , 3 , 4 , 5 . Studies of sensory …

[PDF][PDF] The genetic legacy of the Mongols

…, A Mohyuddin, S Fu, P Li, N Yuldasheva… - The American Journal of …, 2003 - cell.com
We have identified a Y-chromosomal lineage with several unusual features. It was found in
16 populations throughout a large region of Asia, stretching from the Pacific to the Caspian …

The Eurasian heartland: a continental perspective on Y-chromosome diversity

RS Wells, N Yuldasheva… - Proceedings of the …, 2001 - National Acad Sciences
The nonrecombining portion of the human Y chromosome has proven to be a valuable tool
for the study of population history. The maintenance of extended haplotypes characteristic of …

[HTML][HTML] Piezo1 channels sense whole body physical activity to reset cardiovascular homeostasis and enhance performance

…, SJ Lotteau, MA Bailey, NY Yuldasheva… - Nature …, 2017 - nature.com
Mammalian biology adapts to physical activity but the molecular mechanisms sensing the
activity remain enigmatic. Recent studies have revealed how Piezo1 protein senses …

Role of glutamine and interlinked asparagine metabolism in vessel formation

…, A Zecchin, U Brüning, A Visnagri, N Yuldasheva… - The EMBO …, 2017 - embopress.org
Endothelial cell ( EC ) metabolism is emerging as a regulator of angiogenesis, but the precise
role of glutamine metabolism in EC s is unknown. Here, we show that depriving EC s of …

[PDF][PDF] A genetic landscape reshaped by recent events: Y-chromosomal insights into central Asia

T Zerjal, RS Wells, N Yuldasheva, R Ruzibakiev… - The American Journal of …, 2002 - cell.com
Sixteen Y-chromosomal microsatellites and 16 binary markers have been used to analyze
DNA variation in 408 male subjects from 15 populations in Central Asia. Large genetic …

Oxidized LDL activates blood platelets through CD36/NOX2–mediated inhibition of the cGMP/protein kinase G signaling cascade

…, C McNeil, S Wheatcroft, N Yuldasheva… - Blood, The Journal …, 2015 - ashpublications.org
Oxidized low-density lipoprotein (oxLDL) promotes unregulated platelet activation in
dyslipidemic disorders. Although oxLDL stimulates activatory signaling, it is unclear how these …

Pregnenolone sulphate-and cholesterol-regulated TRPM3 channels coupled to vascular smooth muscle secretion and contraction

…, P Sukumar, B Hou, A Sedo, N Yuldasheva… - Circulation …, 2010 - Am Heart Assoc
Rationale: Transient receptor potential melastatin (TRPM)3 is a calcium-permeable ion
channel activated by the neurosteroid pregnenolone sulfate and positively coupled to insulin …

Nox2 NADPH oxidase has a critical role in insulin resistance–related endothelial cell dysfunction

…, H Imrie, RM Cubbon, N Yuldasheva… - Diabetes, 2013 - Am Diabetes Assoc
Insulin resistance is characterized by excessive endothelial cell generation of potentially
cytotoxic concentrations of reactive oxygen species. We examined the role of NADPH oxidase (…

Increasing circulating IGFBP1 levels improves insulin sensitivity, promotes nitric oxide production, lowers blood pressure, and protects against atherosclerosis

A Rajwani, V Ezzat, J Smith, NY Yuldasheva… - Diabetes, 2012 - Am Diabetes Assoc
Low concentrations of insulin-like growth factor (IGF) binding protein-1 (IGFBP1) are associated
with insulin resistance, diabetes, and cardiovascular disease. We investigated whether …