Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …

The neocortex contains a multitude of cell types that are segregated into layers and functionally
distinct areas. To investigate the diversity of cell types across the mouse neocortex, here …

Elucidating the cellular architecture of the human cerebral cortex is central to understanding
our cognitive abilities and susceptibility to disease. Here we used single-nucleus RNA-…

The anatomical and functional architecture of the human brain is mainly determined by prenatal
transcriptional processes. We describe an anatomically comprehensive atlas of the mid-…

The human brain directs complex behaviors, ranging from fine motor skills to abstract
intelligence, but the diversity of cell types that support these skills has not been fully described. In …

The diverse progenitors that give rise to the human neocortex have been difficult to
characterize because progenitors, particularly radial glia (RG), are rare and are defined by a …

During human brain development, multiple signaling pathways generate diverse cell types
with varied regional identities. Here, we integrate single-cell RNA sequencing and clonal …

Viral genetic tools that target specific brain cell types could transform basic neuroscience
and targeted gene therapy. Here, we use comparative open chromatin analysis to identify …

GABAergic interneurons are essential for neural circuit function, and their loss or dysfunction
is implicated in human neuropsychiatric disease. In vitro methods for interneuron …

Increasing interest in studies of prenatal human brain development, particularly using new
single‐cell genomics and anatomical technologies to create cell atlases, creates a strong …