High-dimensional single-cell multimodal landscape of human carotid atherosclerosis
BACKGROUND: Atherosclerotic plaques are complex tissues composed of a heterogeneous
mixture of cells. However, our understanding of the comprehensive transcriptional and …
mixture of cells. However, our understanding of the comprehensive transcriptional and …
ADAMTS-7 modulates atherosclerotic plaque formation by degradation of TIMP-1
…, TA Dang, J Milic, A Moggio, N Sachs… - Circulation …, 2023 - Am Heart Assoc
BACKGROUND: The ADAMTS7 locus was genome-wide significantly associated with coronary
artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin …
artery disease. Lack of the ECM (extracellular matrix) protease ADAMTS-7 (A disintegrin …
Suppression of IL-1β promotes beneficial accumulation of fibroblast-like cells in atherosclerotic plaques in clonal hematopoiesis
…, S Abramowicz, T Xiao, K O'Connor, N Sachs… - Nature cardiovascular …, 2024 - nature.com
Clonal hematopoiesis (CH) is an independent risk factor for atherosclerotic cardiovascular
disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in …
disease. Murine models of CH suggest a central role of inflammasomes and IL-1β in …
[HTML][HTML] Targeting long non-coding RNA NUDT6 enhances smooth muscle cell survival and limits vascular disease progression
…, BB Khomtchouk, DJ Van Booven, N Sachs… - Molecular Therapy, 2023 - cell.com
Long non-coding RNAs (lncRNAs) orchestrate various biological processes and regulate
the development of cardiovascular diseases. Their potential therapeutic benefit to tackle …
the development of cardiovascular diseases. Their potential therapeutic benefit to tackle …
The antituberculosis drug ethambutol selectively blocks apical growth in CMN group bacteria
…, K Böhm, A Rieblinger, L Lindenthal, N Sachs… - MBio, 2017 - Am Soc Microbiol
Members of the genus Mycobacterium are the most prevalent cause of infectious diseases.
Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an …
Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an …
[HTML][HTML] The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms
…, J Roy, R Hultgren, J Pauli, A Busch, N Sachs… - … Therapy-Nucleic Acids, 2023 - cell.com
An abdominal aortic aneurysm (AAA) is a pathological widening of the aortic wall characterized
by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and local …
by loss of smooth muscle cells (SMCs), extracellular matrix degradation, and local …
[HTML][HTML] Heterocomplexes between the atypical chemokine MIF and the CXC-motif chemokine CXCL4L1 regulate inflammation and thrombus formation
…, P Scheiermann, N Tsilimparis, N Sachs… - Cellular and Molecular …, 2022 - Springer
To fulfil its orchestration of immune cell trafficking, a network of chemokines and receptors
developed that capitalizes on specificity, redundancy, and functional selectivity. The discovery …
developed that capitalizes on specificity, redundancy, and functional selectivity. The discovery …
[HTML][HTML] Apolipoprotein E (ApoE) rescues the contractile smooth muscle cell phenotype in popliteal artery aneurysm disease
J Pauli, T Reisenauer, G Winski, N Sachs… - Biomolecules, 2023 - mdpi.com
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in
male smokers with a prevalence below 1%. This exploratory study aims to shed light on …
male smokers with a prevalence below 1%. This exploratory study aims to shed light on …
Utilization of an Artery‐on‐a‐Chip to Unravel Novel Regulators and Therapeutic Targets in Vascular Diseases
…, E Chernogubova, H Jin, N Sachs… - Advanced …, 2024 - Wiley Online Library
In this study, organ‐on‐chip technology is used to develop an in vitro model of medium‐to‐large
size arteries, the artery‐on‐a‐chip (AoC), with the objective to recapitulate the structure …
size arteries, the artery‐on‐a‐chip (AoC), with the objective to recapitulate the structure …
[HTML][HTML] Completing the view–histologic insights from circular AAA specimen including 3D imaging: A methodologic approach towards histologic analysis of …
Abdominal aortic aneurysm (AAA) is a pathologic enlargement of the infrarenal aorta with
an associated risk of rupture. However, the responsible mechanisms are only partially …
an associated risk of rupture. However, the responsible mechanisms are only partially …