Cell-cycle transitions are driven by waves of ubiquitin-dependent degradation of key cell-cycle
regulators. SCF (Skp1/Cullin/F-box protein) complexes and anaphase-promoting …

The tumour suppressor gene RASSF1A is frequently silenced in lung cancer and other sporadic
tumours as a result of hypermethylation of a CpG island in its promoter 1 , 2 , 3 , 4 , 5 , 6 . …

We have identified a regulator of sister chromatid cohesion in a screen for cell cycle-controlled
proteins. This 35 kDa protein is degraded through anaphase-promoting complex (APC)-…

Glioblastoma multiforme (GBM) is the most common and aggressive malignant adult primary
brain tumor. Despite surgical resection followed by radiotherapy and chemotherapy, the …

Bromodomain and extraterminal (BET) domain proteins have emerged as promising
therapeutic targets in glioblastoma and many other cancers. Small molecule inhibitors of BET …

Entry into mitosis requires the activation of cdk1/cyclin B, while mitotic exit is achieved when
the same kinase activity decreases, as cyclin B is degraded. Cyclin B proteolysis is …

Epigenetic proteins have recently emerged as novel anticancer targets. Among these,
bromodomain and extra terminal domain (BET) proteins recognize lysine-acetylated histones, …

Epigenetic enzymes modulate signal transduction pathways in different biological contexts.
We reasoned that epigenetic regulators might modulate the Hedgehog (HH) signaling …

Glioblastoma multiforme (GBM) is the most malignant primary adult brain tumor. The current
standard of care is surgical resection, radiation, and chemotherapy treatment, which extends …

Glioblastoma (GBM) is the most common primary adult brain tumor. Despite extensive efforts,
the median survival for GBM patients is approximately 14 months. GBM therapy could …