Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide
oscillations of energy states as well as a phase transition (depolarization) in response to …

Extracellular vesicles (EVs) facilitate intercellular communication and are considered a
promising therapeutic tool for the treatment of infectious diseases. These vesicles involve …

Mounting evidence implicates chronic oxidative stress as a critical driver of the aging
process. Down syndrome (DS) is characterized by a complex phenotype, including early …

The oncogenic form of HSP90 organizes and maintains functional multienzymatic metabolic
hubs in cancer cells, suggesting the potential of repurposing oncogenic HSP90 selective …

XPO1 regulates the dynamic ribonucleoprotein nuclear export in response to genotoxic
stress to support tolerance and can be targeted to enhance the sensitivity of cancer cells to …

ABC-DLBCLs feature frequent mutations of signaling mediators that converge on the CBM
complex. We use structure–function approaches to reveal that BCL10 mutations fall into two …

T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive and often incurable disease.
To uncover therapeutic vulnerabilities, we first developed T-ALL patient–derived tumor …

Protein S-palmitoylation, a hydrophobic post-translational modification, is performed by
protein acyltransferases that have a common DHHC Cys-rich domain (DHHC proteins), and …

Our understanding of protein and lipid trafficking in eukaryotic cells has been challenged by
the finding of different forms of compartmentalization and cargo processing in protozoan …

Ageing in humans is associated with the decreased capacity to regulate cell physiology.
Cellular properties, such as cell morphology and mechanics, encode ageing information, and …