In single-cell RNA sequencing (scRNA-seq) studies, only a small fraction of the transcripts
present in each cell are sequenced. This leads to unreliable quantification of genes with low …

Abstract Knowledge of cell type composition in disease relevant tissues is an important step
towards the identification of cellular targets of disease. We present MuSiC, a method that …

Objective: To evaluate previously reported associations of copy number variants (CNVs)
with schizophrenia and to identify additional associations, the authors analyzed CNVs in the …

Angiopoietin-2 (Ang2) exhibits broad expression in the remodeling vasculature of human
tumors but very limited expression in normal tissues, making it an attractive candidate target for …

DNA transcription, replication, and repair are regulated by histone acetylation, a process that
requires the generation of acetyl-coenzyme A (CoA). Here, we show that all the subunits of …

In the analysis of data generated by change-point processes, one critical challenge is to
determine the number of change-points. The classic Bayes information criterion (BIC) statistic …

Context.— Regulatory approval of pembrolizumab for treatment of gastric and gastroesophageal
junction (G/GEJ) adenocarcinoma required a reproducible scoring method for use of …

Objective Intensive care units (ICUs) account for an increasing percentage of hospital
admissions and resource consumption. Adverse events are common in ICU patients and …

The intestine is a complex organ that promotes digestion, extracts nutrients, participates in
immune surveillance, maintains critical symbiotic relationships with microbiota and affects …

Interferon-gamma (IFNG) augments immune function yet promotes T cell exhaustion through
PDL1. How these opposing effects are integrated to impact immune checkpoint blockade (…