Background & Objective: Diabetes and neurodegenerative diseases (ND) are progressive
morbidities and represent a major public health burden. A growing body of evidence points …

Cortical expansion in primate brains relies on enlargement of germinal zones during a
prolonged developmental period. Although most mammals have two cortical germinal zones, the …

GABAergic interneurons are key regulators of cortical circuit function. Among the dozens of
reported transcriptionally distinct subtypes of cortical interneurons, neurogliaform cells (NGCs…

Microsomal and soluble epoxide hydrolase (mEH and sEH) fulfill apparently distinct roles:
Whereas mEH detoxifies xenobiotics, sEH hydrolyzes fatty acid (FA) signaling molecules and …

Recent studies suggest a role for the arachidonic acid-derived epoxyeicosatrienoic acids (EETs)
in attenuating epileptic seizures. However, their effect on neurotransmission has never …

Endothelin-1 (ET-1) has been demonstrated to be a pro-nociceptive as well as an anti-nociceptive
agent. However, underlying molecular mechanisms for these pain modulatory actions …

Microsomal epoxide hydrolase (mEH) is a detoxifying enzyme for xenobiotic compounds.
Enzymatic activity of mEH can be greatly increased by a point mutation, leading to an E404D …

Hyperglycemia is the main trigger for diabetic neuropathic pain and can cause degeneration
of the sensory neurons. Here, we explored the effects of high glucose on the cell viability, …

Voltage-gated sodium channels (VGSCs) in sensory neurons play a crucial role in neuropathic
pain. Following nerve injury, alterations in the expression, distribution, kinetics and …

The apical dendrites of layer (L) 2/3 pyramidal neurons in the mouse somatosensory cortex
integrate synaptic input from long-range projections. Among those, inputs from the higher-…