Mitochondrial enzymes involved in energy transformation are organized into multiprotein
complexes that channel the reaction intermediates for efficient ATP production. Three of the …

Background The efficient conversion of ammonia, a potent neurotoxin, into non-toxic metabolites
was an essential adaptation that allowed animals to move from the aquatic to terrestrial …

N-Acetylglutamate synthase (NAGS, EC 2.3.1.1) is a mitochondrial enzyme that catalyzes
the formation of N-acetylglutamate (NAG) from glutamate and acetylcoenzyme A. NAG is an …

AZD7442, a combination of two long-acting monoclonal antibodies (tixagevimab [AZD8895]
and cilgavimab [AZD1061]), has been authorized for the prevention and treatment of …

The urea cycle converts ammonia, a waste product of protein catabolism, into urea. Because
fish dispose ammonia directly into water, the role of the urea cycle in fish remains unknown. …

Over the last two decades, therapeutic antibodies have emerged as a rapidly expanding
domain within the field biologics. In silico tools that can streamline the process of antibody …

N‐acetylglutamate synthase deficiency is an autosomal recessive urea cycle disorder caused
either by decreased expression of the NAGS gene or defective NAGS enzyme resulting in …

Abundance of urea cycle enzymes in the liver is regulated by dietary protein intake. Although
urea cycle enzyme levels rise in response to a high‐protein (HP) diet, signaling networks …

Novel bifunctional N-acetylglutamate synthase/kinases (NAGS/K) that catalyze the first two
steps of arginine biosynthesis and are homologous to vertebrate N-acetylglutamate synthase (…

N-acetylglutamate synthase deficiency (NAGSD, MIM #237310) is an autosomal recessive
disorder of the urea cycle that results from absent or decreased production of N-…