The CRL4 Cdt2 ubiquitin ligase complex is an essential regulator of cell-cycle progression
and genome stability, ubiquitinating substrates such as p21, Set8, and Cdt1, via a display of …

PCNA is a DNA clamp, acting on chromatin as a platform for various proteins involved in
many aspects of DNA replication-linked processes. Most of these proteins have the PCNA-…

The Cullin-RING ubiquitin ligase CRL4 Cdt2 maintains genome integrity by mediating the
cell cycle- and DNA damage-dependent degradation of proteins such as Cdt1, p21 and Set8. …

Numerous cell cycle-regulating proteins are controlled by protein degradation. Recent work
shows that ubiquitination-dependent proteolysis plays an important role in once-per-cell …

A 71-year-old man was transferred urgently to our hospital after collapsing near his home
post the first shot of the BNT162b2 coronavirus disease 2019 vaccine (Pfizer-BioNTech, …

… NAOHIRO SUENAGA• Graduate School of Life Science, University of Hyogo, Hyogo,
Japan MIYUKI TANAKA• Graduate School of Life Science, University of Hyogo, Hyogo, Japan …

The discharge phase and time evolution of a 150 kHz high-power pulse burst discharge was
observed. A vacuum chamber constructed by connecting glass tubes on which a solenoid …

AIM: To examine the long term survival of geriatric patients treated with percutaneous
endoscopic gastrostomy (PEG) in Japan. METHODS: We retrospectively included 46 Japanese …

Background The current surgical procedures for irreparable rotator cuff tears have considerable
limitations. Tissue engineering techniques using novel scaffold materials offer potential …

Introduction Gastric adenocarcinomas with low grade atypia may be difficult to diagnose as
gastric cancer by preoperative biopsy. We report an extremely well-differentiated …