Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides

N Iwamoto, DCD Butler, N Svrzikapa… - Nature …, 2017 - nature.com
Whereas stereochemical purity in drugs has become the standard for small molecules,
stereoisomeric mixtures containing as many as a half million components persist in antisense …

The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM

…, Y Horai, A Okada, S Kawashiri, N Iwamoto… - …, 2012 - academic.oup.com
Objective. Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a
major poor prognostic factor in patients with DM. We investigated the association of anti-…

Collective modes in nonrelativistic electron-positron plasmas

N Iwamoto - Physical Review E, 1993 - APS
The longitudinal and transverse collective modes in a nonrelativistic electron-positron
plasma are studied in two cases: a static uniform magnetic field is present or absent. The …

Neutrino emissivities and mean free paths of degenerate quark matter

N Iwamoto - Annals of Physics, 1982 - Elsevier
The neutrino properties of quark matter are investigated by calculating the neutrino emissivities
and mean free paths. It is shown that the simple β decay reactions, d → u + e − + v e and …

Disruption of tumor necrosis factor-α gene diminishes the development of atherosclerosis in ApoE-deficient mice

H Ohta, H Wada, T Niwa, H Kirii, N Iwamoto, H Fujii… - Atherosclerosis, 2005 - Elsevier
Inflammatory cytokines, including tumor necrosis factor-α (TNF-α) have been implicated in
atherogenesis. However, the precise role of TNF-α in atherogenesis is still unclear. To …

Antidiabetic activity of a xanthone compound, mangiferin

T Miura, H Ichiki, I Hashimoto, N Iwamoto, M Kao… - Phytomedicine, 2001 - Elsevier
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for
antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood …

Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice

T Miura, C Itoh, N Iwamoto, M Kato, M Kawai… - Journal of nutritional …, 2001 - jstage.jst.go.jp
… Toshihiro MIURA1,*, Chisa ITOH1, Naoki IWAMOTO1, Motoshi KATO1, Masaomi KAWAI1,
Sang Rae PARK2 and Ikukatsu SUZUKI1 …

Axion emission from neutron stars

N Iwamoto - Physical review letters, 1984 - APS
We show that axion emission from neutron stars is the dominant energy-loss mechanism for
a range of values of the Peccei-Quinn symmetry-breaking scale (F) not excluded by …

[HTML][HTML] M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1/M2 monocytes to osteoclastogenesis

S Fukui, N Iwamoto, A Takatani, T Igawa… - Frontiers in …, 2018 - frontiersin.org
Objectives We investigated the relationships among M1 monocytes, M2 monocytes, osteoclast
(OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (…

Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides

…, F Favaloro, J Godfrey, A Hoss, N Iwamoto… - Nature …, 2022 - nature.com
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to
specific cellular RNAs have therapeutic potential, but translating them from cell culture into …