Control of phosphorothioate stereochemistry substantially increases the efficacy of antisense oligonucleotides
N Iwamoto, DCD Butler, N Svrzikapa… - Nature …, 2017 - nature.com
Whereas stereochemical purity in drugs has become the standard for small molecules,
stereoisomeric mixtures containing as many as a half million components persist in antisense …
stereoisomeric mixtures containing as many as a half million components persist in antisense …
The diagnostic utility of anti-melanoma differentiation-associated gene 5 antibody testing for predicting the prognosis of Japanese patients with DM
…, Y Horai, A Okada, S Kawashiri, N Iwamoto… - …, 2012 - academic.oup.com
Objective. Interstitial lung disease (ILD), especially rapidly progressive ILD (RPILD), is a
major poor prognostic factor in patients with DM. We investigated the association of anti-…
major poor prognostic factor in patients with DM. We investigated the association of anti-…
Collective modes in nonrelativistic electron-positron plasmas
N Iwamoto - Physical Review E, 1993 - APS
The longitudinal and transverse collective modes in a nonrelativistic electron-positron
plasma are studied in two cases: a static uniform magnetic field is present or absent. The …
plasma are studied in two cases: a static uniform magnetic field is present or absent. The …
Neutrino emissivities and mean free paths of degenerate quark matter
N Iwamoto - Annals of Physics, 1982 - Elsevier
The neutrino properties of quark matter are investigated by calculating the neutrino emissivities
and mean free paths. It is shown that the simple β decay reactions, d → u + e − + v e and …
and mean free paths. It is shown that the simple β decay reactions, d → u + e − + v e and …
Disruption of tumor necrosis factor-α gene diminishes the development of atherosclerosis in ApoE-deficient mice
H Ohta, H Wada, T Niwa, H Kirii, N Iwamoto, H Fujii… - Atherosclerosis, 2005 - Elsevier
Inflammatory cytokines, including tumor necrosis factor-α (TNF-α) have been implicated in
atherogenesis. However, the precise role of TNF-α in atherogenesis is still unclear. To …
atherogenesis. However, the precise role of TNF-α in atherogenesis is still unclear. To …
Antidiabetic activity of a xanthone compound, mangiferin
T Miura, H Ichiki, I Hashimoto, N Iwamoto, M Kao… - Phytomedicine, 2001 - Elsevier
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for
antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood …
antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood …
Hypoglycemic activity of the fruit of the Momordica charantia in type 2 diabetic mice
T Miura, C Itoh, N Iwamoto, M Kato, M Kawai… - Journal of nutritional …, 2001 - jstage.jst.go.jp
… Toshihiro MIURA1,*, Chisa ITOH1, Naoki IWAMOTO1, Motoshi KATO1, Masaomi KAWAI1,
Sang Rae PARK2 and Ikukatsu SUZUKI1 …
Sang Rae PARK2 and Ikukatsu SUZUKI1 …
Axion emission from neutron stars
N Iwamoto - Physical review letters, 1984 - APS
We show that axion emission from neutron stars is the dominant energy-loss mechanism for
a range of values of the Peccei-Quinn symmetry-breaking scale (F) not excluded by …
a range of values of the Peccei-Quinn symmetry-breaking scale (F) not excluded by …
[HTML][HTML] M1 and M2 monocytes in rheumatoid arthritis: a contribution of imbalance of M1/M2 monocytes to osteoclastogenesis
S Fukui, N Iwamoto, A Takatani, T Igawa… - Frontiers in …, 2018 - frontiersin.org
Objectives We investigated the relationships among M1 monocytes, M2 monocytes, osteoclast
(OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (…
(OC) differentiation ability, and clinical characteristics in patients with rheumatoid arthritis (…
Endogenous ADAR-mediated RNA editing in non-human primates using stereopure chemically modified oligonucleotides
…, F Favaloro, J Godfrey, A Hoss, N Iwamoto… - Nature …, 2022 - nature.com
Technologies that recruit and direct the activity of endogenous RNA-editing enzymes to
specific cellular RNAs have therapeutic potential, but translating them from cell culture into …
specific cellular RNAs have therapeutic potential, but translating them from cell culture into …