User profiles for Naomi Habib
Naomi HabibHebrew University of Jerusalem Israel Verified email at elsc.huji.ac.il Cited by 29778 |
Disease-associated astrocytes in Alzheimer's disease and aging
N Habib, C McCabe, S Medina, M Varshavsky… - Nature …, 2020 - nature.com
The role of non-neuronal cells in Alzheimer’s disease progression has not been fully
elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-…
elucidated. Using single-nucleus RNA sequencing, we identified a population of disease-…
[HTML][HTML] Single cell RNA sequencing of human microglia uncovers a subset associated with Alzheimer's disease
The extent of microglial heterogeneity in humans remains a central yet poorly explored question
in light of the development of therapies targeting this cell type. Here, we investigate the …
in light of the development of therapies targeting this cell type. Here, we investigate the …
Multiplex genome engineering using CRISPR/Cas systems
Functional elucidation of causal genetic variants and elements requires precise genome
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short …
editing technologies. The type II prokaryotic CRISPR (clustered regularly interspaced short …
Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex
Systematic interrogation of gene function requires the ability to perturb gene expression in a
robust and generalizable manner. Here we describe structure-guided engineering of a …
robust and generalizable manner. Here we describe structure-guided engineering of a …
[HTML][HTML] Paternally induced transgenerational environmental reprogramming of metabolic gene expression in mammals
Epigenetic information can be inherited through the mammalian germline and represents a
plausible transgenerational carrier of environmental information. To test whether …
plausible transgenerational carrier of environmental information. To test whether …
[HTML][HTML] Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5′ sites
N6-methyladenosine (m6A) is a common modification of mRNA with potential roles in fine-tuning
the RNA life cycle. Here, we identify a dense network of proteins interacting with …
the RNA life cycle. Here, we identify a dense network of proteins interacting with …
[HTML][HTML] Densely interconnected transcriptional circuits control cell states in human hematopoiesis
Though many individual transcription factors are known to regulate hematopoietic differentiation,
major aspects of the global architecture of hematopoiesis remain unknown. Here, we …
major aspects of the global architecture of hematopoiesis remain unknown. Here, we …
Massively parallel single-nucleus RNA-seq with DroNc-seq
Single-nucleus RNA sequencing (sNuc-seq) profiles RNA from tissues that are preserved or
cannot be dissociated, but it does not provide high throughput. Here, we develop DroNc-seq…
cannot be dissociated, but it does not provide high throughput. Here, we develop DroNc-seq…
In vivo interrogation of gene function in the mammalian brain using CRISPR-Cas9
L Swiech, M Heidenreich, A Banerjee, N Habib… - Nature …, 2015 - nature.com
Probing gene function in the mammalian brain can be greatly assisted with methods to
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …
manipulate the genome of neurons in vivo. The clustered, regularly interspaced, short …
[HTML][HTML] Stroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke — the second leading cause
of death worldwide — were conducted predominantly in populations of European ancestry 1 …
of death worldwide — were conducted predominantly in populations of European ancestry 1 …