Structure–activity relationship of ghrelin: pharmacological study of ghrelin peptides
…, H Hosoda, Y Kitajima, N Morozumi… - Biochemical and …, 2001 - Elsevier
Ghrelin, a novel peptide purified from the stomach, is the endogenous ligand of the growth
hormone secretagogue receptor. The Ser 3 residue of ghrelin is modified with a lipid n-…
hormone secretagogue receptor. The Ser 3 residue of ghrelin is modified with a lipid n-…
[HTML][HTML] Exogenous C-type natriuretic peptide restores normal growth and prevents early growth plate closure in its deficient rats
K Hirota, M Furuya, N Morozumi, K Yoshikiyo… - PLoS …, 2018 - journals.plos.org
Signaling by C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor-B,
is a pivotal stimulator of endochondral bone growth. We recently developed CNP knockout (…
is a pivotal stimulator of endochondral bone growth. We recently developed CNP knockout (…
[HTML][HTML] Rats deficient C-type natriuretic peptide suffer from impaired skeletal growth without early death
T Fujii, K Hirota, A Yasoda, A Takizawa, N Morozumi… - PLoS …, 2018 - journals.plos.org
We have previously investigated the physiological role of C-type natriuretic peptide (CNP)
on endochondral bone growth, mainly with mutant mouse models deficient in CNP, and …
on endochondral bone growth, mainly with mutant mouse models deficient in CNP, and …
The role of C-terminal part of ghrelin in pharmacokinetic profile and biological activity in rats
N Morozumi, T Hanada, H Habara, A Yamaki, M Furuya… - Peptides, 2011 - Elsevier
Ghrelin is an endogenous ligand for growth hormone secretagogue receptor 1a (GHS-R1a),
and consists of 28 amino acid residues with octanoyl modification at Ser 3 . The previous …
and consists of 28 amino acid residues with octanoyl modification at Ser 3 . The previous …
Discovery and in vivo effects of novel human natriuretic peptide receptor A (NPR-A) agonists with improved activity for rat NPR-A
…, Y Okamura, A Yamaki, M Iwanami, N Morozumi… - Bioorganic & medicinal …, 2017 - Elsevier
Natriuretic peptide receptor A (NPR-A) agonists were evaluated in vivo by optimizing the
structure of quinazoline derivatives to improve agonistic activity for rat NPR-A. A 1,4-Cis-…
structure of quinazoline derivatives to improve agonistic activity for rat NPR-A. A 1,4-Cis-…
[HTML][HTML] ASB20123: A novel C-type natriuretic peptide derivative for treatment of growth failure and dwarfism
N Morozumi, T Yotsumoto, A Yamaki, K Yoshikiyo… - PLoS …, 2019 - journals.plos.org
C-type natriuretic peptide (CNP) and its receptor natriuretic peptide receptor B (NPR-B) are
physiological potent positive regulators of endochondral bone growth; therefore, the CNP/…
physiological potent positive regulators of endochondral bone growth; therefore, the CNP/…
C-type natriuretic peptide improves growth retardation in a mouse model of cardio-facio-cutaneous syndrome
S Inoue, N Morozumi, K Yoshikiyo… - Human Molecular …, 2019 - academic.oup.com
Cardio-facio-cutaneous (CFC) syndrome, a genetic disorder caused by germline mutations
in BRAF, KRAS, MAP2K1 and MAP2K2, is characterized by growth retardation, heart defects, …
in BRAF, KRAS, MAP2K1 and MAP2K2, is characterized by growth retardation, heart defects, …
Design and evaluation of novel natriuretic peptide derivatives with improved pharmacokinetic and pharmacodynamic properties
N Morozumi, S Sato, S Yoshida, Y Harada, M Furuya… - Peptides, 2017 - Elsevier
C-type natriuretic peptide (CNP) and its receptor, natriuretic peptide receptor B (NPR-B), are
potent positive regulators of endochondral bone growth, making the CNP pathway one of …
potent positive regulators of endochondral bone growth, making the CNP pathway one of …
A pertussis toxin-sensitive GTP-binding protein plays a role in the G0-G1 transition of rat hepatocytes following establishment in primary culture
Y Fujinaga, N Morozumi, K Sato, Y Tokumitsu… - FEBS letters, 1989 - Elsevier
Acute spontaneous c-myc gene expression and sustained increase of a GTP-binding protein(s)
(G-protein) which is sensitive to islet-activating protein (IAP), pertussis toxin, occurred …
(G-protein) which is sensitive to islet-activating protein (IAP), pertussis toxin, occurred …
[HTML][HTML] Safety assessment of a novel C-type natriuretic peptide derivative and the mechanism of bone-and cartilage-specific toxicity
T Yotsumoto, N Morozumi, R Nakamura, T Jindo… - PloS one, 2019 - journals.plos.org
ASB20123, a C-type natriuretic peptide/ghrelin chimeric peptide, was designed as a novel
peptide and demonstrated full agonistic activity for natriuretic-peptide receptor B and a …
peptide and demonstrated full agonistic activity for natriuretic-peptide receptor B and a …