Our understanding of dysfunction of the gastrointestinal system in patients with Parkinson's
disease has increased substantially in the past decade. The entire gastrointestinal tract is …

Parkinson’s disease (PD) is a progressive neurodegenerative disorder typified by the
presence of intraneuronal inclusions containing aggregated alpha synuclein (αsyn). The …

The clinical and pathological differences between synucleinopathies such as Parkinson’s
disease and multiple system atrophy have been postulated to stem from unique strains of α-…

Well‐formed visual hallucinations (VH) are common in patients with Parkinson's disease (PD).
The pathophysiology of VH in PD is unknown but may involve structures mediating visual …

In recent years, a new generation of animal models of Parkinson's disease (PD) based on
ectopic expression, overexpression, or intracerebral injection of the protein α-synuclein have …

α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD).
AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey …

Objective: To determine the utility of detecting α-synuclein (αSyn) in colonic mucosal biopsy
tissue as a potential diagnostic biomarker for Parkinson disease (PD). Methods: We used …

α-Synuclein is an abundant presynaptic protein and a primary component of Lewy bodies in
Parkinson disease. Although its pathogenic role remains unclear, in healthy nerve terminals …

Background Multiple system atrophy (MSA) is a neurodegenerative condition characterized
by variable combinations of parkinsonism, autonomic failure, cerebellar ataxia and …

Leucine-rich repeat kinase 2 (LRRK2) has been implicated in both familial and sporadic
Parkinson’s disease (PD), yet its pathogenic role remains unclear. A previous screen in …