ToxinPred2: an improved method for predicting toxicity of proteins

N Sharma, LD Naorem, S Jain… - Briefings in …, 2022 - academic.oup.com
Proteins/peptides have shown to be promising therapeutic agents for a variety of diseases.
However, toxicity is one of the obstacles in protein/peptide-based therapy. The current study …

A web server for predicting and scanning of IL-5 inducing peptides using alignment-free and alignment-based method

LD Naorem, N Sharma, GPS Raghava - Computers in Biology and …, 2023 - Elsevier
Interleukin-5 (IL-5) can act as an enticing therapeutic target due to its pivotal role in several
eosinophil-mediated diseases. The aim of this study is to develop a model for predicting IL-5 …

Identification of dysregulated miRNAs in triple negative breast cancer: a meta‐analysis approach

LD Naorem, M Muthaiyan… - Journal of cellular …, 2019 - Wiley Online Library
Triple negative breast cancer (TNBC) is an aggressive subtype of breast cancer with poor
clinical outcomes and lack of approved targeted therapy. Dysregulated microRNAs (miRNAs) …

ChAlPred: A web server for prediction of allergenicity of chemical compounds

N Sharma, S Patiyal, A Dhall, NL Devi… - Computers in Biology …, 2021 - Elsevier
Background Allergy is the abrupt reaction of the immune system that may occur after the
exposure to allergens such as proteins, peptides, or chemicals. In the past, various methods …

Comprehensive analysis of dysregulated lncRNAs and their competing endogenous RNA network in triple-negative breast cancer

LD Naorem, VS Prakash, M Muthaiyan… - International journal of …, 2020 - Elsevier
The study aimed to explore the molecular mechanism underlying triple-negative breast cancer
(TNBC) and to identify their potential diagnostic/prognostic biomarkers. The differentially …

Integrated network analysis and machine learning approach for the identification of key genes of triple‐negative breast cancer

LD Naorem, M Muthaiyan… - Journal of cellular …, 2019 - Wiley Online Library
Triple‐negative breast cancer (TNBC) has attracted more attention compared with other
breast cancer subtypes due to its aggressive nature, poor prognosis, and chemotherapy …

Computational resources in healthcare

N Sharma, LD Naorem, S Gupta… - … Reviews: Data Mining …, 2022 - Wiley Online Library
Healthcare is the most important component in the life of all human beings as each individual
wish to have happy, healthy, and wealthy life‐span. Most of the branches of science are …

Computer-aided prediction of inhibitors against STAT3 for managing COVID-19 associated cytokine storm

A Dhall, S Patiyal, N Sharma, NL Devi… - Computers in biology and …, 2021 - Elsevier
Background Proinflammatory cytokines are correlated with the severity of disease in patients
with COVID-19. IL6-mediated activation of STAT3 proliferates proinflammatory responses …

[HTML][HTML] Prognostic biomarkers for predicting papillary thyroid carcinoma patients at high risk using nine genes of apoptotic pathway

C Arora, D Kaur, LD Naorem, GPS Raghava - PLoS One, 2021 - journals.plos.org
Aberrant expressions of apoptotic genes have been associated with papillary thyroid carcinoma
(PTC) in the past, however, their prognostic role and utility as biomarkers remains poorly …

Identification of potential key genes related to idiopathic male infertility using RNA-sequencing data: an in-silico approach

LK Lukkani, LD Naorem, M Muthaiyan… - Human …, 2023 - Taylor & Francis
Among reproductive health problems, idiopathic infertility affects married couples. The
current diagnosis of male infertility focuses on the concentration, motility, and morphology of …