The most common cystic fibrosis mutation, ΔF508 in nucleotide binding domain 1 (NBD1),
impairs cystic fibrosis transmembrane conductance regulator (CFTR)-coupled domain folding, …

Mutations in the ubiquitin ligase parkin are responsible for a familial form of Parkinson’s
disease. Parkin and the PINK1 kinase regulate a quality-control system for mitochondria. PINK1 …

Mutations in PINK1 cause autosomal-recessive Parkinson's disease. Mitochondrial damage
results in PINK1 import arrest on the translocase of the outer mitochondrial membrane (TOM…

Mutations in PINK 1 cause autosomal recessive Parkinson's disease ( PD ), a neurodegenerative
movement disorder. PINK 1 is a kinase that acts as a sensor of mitochondrial damage …

The folding/misfolding and pharmacological rescue of multidomain ATP-binding cassette (ABC)
C-subfamily transporters, essential for organismal health, remain incompletely …

The enzymatic mechanism by which retaining glycosyltransferases (GTs) transfer monosaccharides
with net retention of the anomeric configuration has, so far, resisted elucidation. Here…

The human neuraminidases (NEU) consist of a family of four isoforms (NEU1–NEU4).
Members of this enzyme family are proposed to have important roles in health and disease …

An investigation of the nonspecific association of small charged biomolecules and proteins
in electrospray ionization mass spectrometry (ES-MS) is described. Aqueous solutions …

Affinities of the human blood group glycosyltransferases, α-(1→3)-N-acetylgalactosaminyltransferase
(GTA) and α-(1→3)-galactosyltransferase (GTB) for their common acceptor …

The enzyme UDP-glucose:glycoprotein glucosyltransferase (UGGT) mediates quality control
of glycoproteins in the endoplasmic reticulum by attaching glucose to N-linked glycan of …