User profiles for Naoya Hino
 | Naoya HinoIST Austria Verified email at ist.ac.at Cited by 320 |
[PDF][PDF] ERK-mediated mechanochemical waves direct collective cell polarization
During collective migration of epithelial cells, the migration direction is aligned over a tissue-scale
expanse. Although the collective cell migration is known to be directed by mechanical …
expanse. Although the collective cell migration is known to be directed by mechanical …
[PDF][PDF] A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration
Upon the initiation of collective cell migration, the cells at the free edge are specified as leader
cells; however, the mechanism underlying the leader cell specification remains elusive. …
cells; however, the mechanism underlying the leader cell specification remains elusive. …
An amphipathic helix of vinexin α is necessary for a substrate stiffness-dependent conformational change in vinculin
Extracellular matrix (ECM) stiffness regulates various cell behaviors, including cell
differentiation, proliferation and migration. Vinculin and vinexin α (an isoform encoded by the …
differentiation, proliferation and migration. Vinculin and vinexin α (an isoform encoded by the …
Theory of mechanochemical patterning and optimal migration in cell monolayers
Collective cell migration offers a rich field of study for non-equilibrium physics and cellular
biology, revealing phenomena such as glassy dynamics, pattern formation and active …
biology, revealing phenomena such as glassy dynamics, pattern formation and active …
[HTML][HTML] Stretching the limits of extracellular signal-related kinase (ERK) signaling—cell mechanosensing to ERK activation
Extracellular signal-regulated kinase (ERK) has been recognized as a critical regulator in
various physiological and pathological processes. Extensive research has elucidated the …
various physiological and pathological processes. Extensive research has elucidated the …
Redundant roles of EGFR ligands in the ERK activation waves during collective cell migration
Epidermal growth factor receptor (EGFR) plays a pivotal role in collective cell migration by
mediating cell-to-cell propagation of extracellular signal-regulated kinase (ERK) activation. …
mediating cell-to-cell propagation of extracellular signal-regulated kinase (ERK) activation. …
[PDF][PDF] Calcium sparks enhance the tissue fluidity within epithelial layers and promote apical extrusion of transformed cells
In vertebrates, newly emerging transformed cells are often apically extruded from epithelial
layers through cell competition with surrounding normal epithelial cells. However, the …
layers through cell competition with surrounding normal epithelial cells. However, the …
Knockout of all ErbB-family genes delineates their roles in proliferation, survival and migration
The ErbB-family receptors play pivotal roles in the proliferation, migration and survival of
epithelial cells. Because our knowledge on the ErbB-family receptors has been largely obtained …
epithelial cells. Because our knowledge on the ErbB-family receptors has been largely obtained …
Redundant and specific roles of EGFR ligands in the ERK activation waves during collective cell migration of MDCK Cells
Epidermal growth factor receptor (EGFR) plays a pivotal role in collective cell migration by
mediating cell-to-cell propagation of extracellular signal-regulated kinase (ERK) activation. …
mediating cell-to-cell propagation of extracellular signal-regulated kinase (ERK) activation. …
A series of commentaries for a symposium entitled “session 3SDA-optogenetics: applying photoreceptor for understanding biological phenomena”
SP Tsunoda, K Inoue - Biophysical Reviews, 2020 - Springer
… Naoya Hino presented his study entitled “ERK activation waves mediated by intercellular
mechanical signals during collective cell migration” (Fig. 1f). He introduced a novel optogenetic …
mechanical signals during collective cell migration” (Fig. 1f). He introduced a novel optogenetic …