The main protease (M pro ) of SARS-CoV-2 is a key antiviral drug target. While most M pro
inhibitors have a γ-lactam glutamine surrogate at the P1 position, we recently found that …

Objective Recent clinical studies have shown that anticoagulant therapy might be effective
only in specific at-risk subgroups of patients with sepsis and coagulation dysfunction. The …

In recent years, advances in drug therapy for head and neck squamous cell carcinoma (HNSCC)
have progressed rapidly. In addition to cytotoxic anti-cancer agents such as platinum-…

The main protease (M pro ) of SARS-CoV-2 is a validated antiviral drug target. Several M pro
inhibitors have been reported with potent enzymatic inhibition and cellular antiviral activity, …

We investigate the nonlinear response arising during unloading under in-plane uniaxial
compression of a rolled magnesium alloy sheet using a crystal plasticity finite-element method, …

Chronic inflammation caused by infections has been suggested to be one of the most important
cause of cancers. It has recently been shown that there is correlation between intestinal …

Mice are the most commonly used laboratory animals for studying diseases, behaviour, and
pharmacology. Behavioural experiment battery aids in evaluating abnormal behaviour in …

Post-translational modifications (PTMs) provide a rapid response to stimuli, finely tuning
metabolism and gene expression and maintain homeostasis. Advances in mass spectrometry …

Background With advances in the treatment of sepsis, the systemic inflammatory response
syndrome (SIRS) has been losing its prognostic power. Since the SIRS category is no longer …

Cognitive function declines with age. Such function depends on γ-oscillation in the frontal
cortex. Pyramidal neurons, and the parvalbumin-expressing interneurons (PV neurons) that …