Genetic variation modulates protein expression through both transcriptional and post-transcriptional
mechanisms. To characterize the consequences of natural genetic diversity on the …

Meiotic recombination generates new genetic variation and assures the proper segregation
of chromosomes in gametes. PRDM9, a zinc finger protein with histone methyltransferase …

Massively parallel RNA sequencing (RNA-seq) has yielded a wealth of new insights into
transcriptional regulation. A first step in the analysis of RNA-seq data is the alignment of short …

… The authors wish it to be known that, in their opinion, Narayanan Raghupathy and … alternative
to the transcript isoform model presented here (Raghupathy et al., unpublished). EMASE …

Isogenic laboratory mouse strains enhance reproducibility because individual animals are
genetically identical. For the most widely used isogenic strain, C57BL/6, there exists a wealth …

Mouse embryonic stem cells (mESCs) cultured in the presence of LIF occupy a ground state
with highly active pluripotency-associated transcriptional and epigenetic circuitry. However, …

Some imprinted genes exhibit parental origin specific expression bias rather than being
transcribed exclusively from one copy. The physiological relevance of this remains poorly …

Allele-specific expression (ASE) at single-cell resolution is a critical tool for understanding
the stochastic and dynamic features of gene expression. However, low read coverage and …

RNA editing refers to post-transcriptional processes that alter the base sequence of RNA.
Recently, hundreds of new RNA editing targets have been reported. However, the …

Identifying genomic regions that descended from a common ancestor is important for
understanding the function and evolution of genomes. In distantly related genomes, clusters of …