User profiles for Nasa Sinnott-Armstrong
 | Nasa Sinnott-ArmstrongFred Hutchinson Cancer Center Verified email at fredhutch.org Cited by 16064 |
Genetics of 35 blood and urine biomarkers in the UK Biobank
Clinical laboratory tests are a critical component of the continuum of care. We evaluate the
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 …
genetic basis of 35 blood and urine laboratory measurements in the UK Biobank (n = 363,228 …
[HTML][HTML] Opportunities and challenges for transcriptome-wide association studies
Transcriptome-wide association studies (TWAS) integrate genome-wide association studies
(GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective…
(GWAS) and gene expression datasets to identify gene–trait associations. In this Perspective…
GWAS of three molecular traits highlights core genes and pathways alongside a highly polygenic background
Genome-wide association studies (GWAS) have been used to study the genetic basis of a
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
wide variety of complex diseases and other traits. We describe UK Biobank GWAS results for …
[HTML][HTML] Analyses of non-coding somatic drivers in 2,658 cancer whole genomes
…, N Sidiropoulos, L Sieverling, N Sinnott-Armstrong… - Nature, 2020 - nature.com
The discovery of drivers of cancer has traditionally focused on protein-coding genes 1 , 2 , 3
– 4 . Here we present analyses of driver point mutations and structural variants in non-…
– 4 . Here we present analyses of driver point mutations and structural variants in non-…
Discovery of common and rare genetic risk variants for colorectal cancer
…, DM Levine, SC Nelson, NA Sinnott-Armstrong… - Nature …, 2019 - nature.com
To further dissect the genetic architecture of colorectal cancer (CRC), we performed whole-genome
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …
sequencing of 1,439 cases and 720 controls, imputed discovered sequence variants …
Sex-specific genetic effects across biomarkers
…, RB Altman, N Sinnott-Armstrong… - European Journal of …, 2021 - nature.com
Sex differences have been shown in laboratory biomarkers; however, the extent to which
this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters (…
this is due to genetics is unknown. In this study, we infer sex-specific genetic parameters (…
Chromatin accessibility dynamics in a model of human forebrain development
INTRODUCTION The cerebral cortex is responsible for higher-order functions in the nervous
system and has undergone substantial expansion in size in primates. The development of …
system and has undergone substantial expansion in size in primates. The development of …
Large-scale genome-wide association study of coronary artery disease in genetically diverse populations
We report a genome-wide association study (GWAS) of coronary artery disease (CAD)
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …
incorporating nearly a quarter of a million cases, in which existing studies are integrated with data …
SARS-CoV-2 RNA in wastewater settled solids is associated with COVID-19 cases in a large urban sewershed
…, MK Wolfe, D Catoe, N Sinnott-Armstrong… - … science & technology, 2020 - ACS Publications
Wastewater-based epidemiology may be useful for informing public health response to viral
diseases like COVID-19 caused by SARS-CoV-2. We quantified SARS-CoV-2 RNA in …
diseases like COVID-19 caused by SARS-CoV-2. We quantified SARS-CoV-2 RNA in …
Reduced signal for polygenic adaptation of height in UK Biobank
10.7554/eLife.39725.001 Several recent papers have reported strong signals of selection
on European polygenic height scores. These analyses used height effect estimates from the …
on European polygenic height scores. These analyses used height effect estimates from the …