Intracerebral vector delivery in nonhuman primates has been a major challenge. We report
successful blood-brain barrier opening and focal delivery of adeno-associated virus serotype …

When James Parkinson described the classical symptoms of the disease he could hardly
foresee the evolution of our understanding over the next two hundred years. Nowadays, …

The motor features of Parkinson's disease (PD) are well known to manifest only when
striatal dopaminergic deficit reaches 60–70%. Thus, PD has a long pre-symptomatic and pre-…

Despite unprecedented global efforts to rapidly develop SARS-CoV-2 treatments, in order to
reduce the burden placed on health systems, the situation remains critical. Effective …

Degeneration of neurons and circuits across the striatum shows stereotyped time-course and
spatial topography patterns that are distinct for Huntington's disease, Parkinson's disease, …

Aims The striatum is mainly composed of projection neurons. It also contains interneurons,
which modulate and control striatal output. The aim of the present study was to assess the …

Research with animal models has led to critical health advances that have saved or
improved the lives of millions of human beings. Specifically, nonhuman primate’s genetic and …

Administration of recombinant glial cell line-derived neurotrophic factor into the putamen has
been tested in preclinical and clinical studies to evaluate its neuroprotective effects on the …

Introduction: Parkinson’s disease is a progressive neurodegenerative disease that affects
millions of elderly individuals worldwide. Despite intensive efforts dedicated to find a better …

Dopaminergic denervation in patients with Parkinson's disease is associated with changes
in brain metabolism. Cerebral in-vivo mapping of glucose metabolism has been studied in …