miRNAs control insulin content in pancreatic β‐cells via downregulation of transcriptional repressors
MicroRNAs (miRNAs) were shown to be important for pancreas development, yet their roles
in differentiated β‐cells remain unclear. Here, we show that miRNA inactivation in β‐cells of …
in differentiated β‐cells remain unclear. Here, we show that miRNA inactivation in β‐cells of …
[PDF][PDF] Spatiotemporal proteomic analysis of stress granule disassembly using APEX reveals regulation by SUMOylation and links to ALS pathogenesis
…, A Siany, N Kedersha, N Knafo, N Rivkin… - Molecular cell, 2020 - cell.com
Stress granules (SGs) are cytoplasmic assemblies of proteins and non-translating mRNAs.
Whereas much has been learned about SG formation, a major gap remains in understanding …
Whereas much has been learned about SG formation, a major gap remains in understanding …
Whole-genome sequencing reveals that variants in the interleukin 18 receptor accessory protein 3′ UTR protect against ALS
…, E Yanowski, H Marmor-Kollet, N Rivkin… - Nature …, 2022 - nature.com
The noncoding genome is substantially larger than the protein-coding genome but has been
largely unexplored by genetic association studies. Here, we performed region-based rare …
largely unexplored by genetic association studies. Here, we performed region-based rare …
Combining Comparative Sequence and Genomic Data to Ascertain Phylogenetic Relationships and Explore the Evolution of the Large GDSL-Lipase Family in Land …
M Volokita, T Rosilio-Brami, N Rivkin… - Molecular Biology and …, 2011 - academic.oup.com
The GDSL-lipase gene family is a very large subfamily within the supergene family of SGNH
esterases, defined by the distinct GDSL amino acid motif and several highly conserved …
esterases, defined by the distinct GDSL amino acid motif and several highly conserved …
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis
10.7554/eLife.01964.001 Genome-encoded microRNAs (miRNAs) provide a posttranscriptional
regulatory layer that controls the differentiation and function of various cellular systems, …
regulatory layer that controls the differentiation and function of various cellular systems, …
MicroRNA‐142 controls thymocyte proliferation
T‐cell development is a spatially and temporally regulated process, orchestrated by well‐defined
contributions of transcription factors and cytokines. Here, we identify the noncoding …
contributions of transcription factors and cytokines. Here, we identify the noncoding …
[HTML][HTML] Erythrocyte survival is controlled by microRNA-142
Hematopoietic–specific microRNA-142 is a critical regulator of various blood cell lineages,
but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 …
but its role in erythrocytes is unexplored. Herein, we characterize the impact of microRNA-142 …
[HTML][HTML] Rac1 functions downstream of miR-142 in regulation of erythropoiesis
Hematopoietic-specific miR-142 is a critical regulator of various blood cell lineages including
CD4+ dendritic cells1 and platelet biogenesis in megakaryocytes. 2 Furthermore, we …
CD4+ dendritic cells1 and platelet biogenesis in megakaryocytes. 2 Furthermore, we …
Non-coding genetic analysis implicates interleukin 18 receptor accessory protein 3′ UTR in amyotrophic lateral sclerosis
The non-coding genome is substantially larger than the protein-coding genome, but the lack
of appropriate methodologies for identifying functional variants limits genetic association …
of appropriate methodologies for identifying functional variants limits genetic association …
A nuclear role for ARGONAUTE-2 in regulation of neuronal alternative polyadenylation
Argonaute 2 (AGO2), the effector protein partner of microRNAs (miRNAs) in the cytoplasmic
RNA induced silencing complex, is further involved in nuclear RNA processing. However, a …
RNA induced silencing complex, is further involved in nuclear RNA processing. However, a …