Telomeres prevent chromosome ends from being repaired as double‐strand breaks (DSBs).
Telomere identity in Drosophila is determined epigenetically with no sequence either …

The nucleus of oocytes (germinal vesicle) is unusually large and its nuclear envelope (NE)
is densely packed with nuclear pore complexes (NPCs) that are stockpiled for embryonic …

Chromatin remodeling during sperm maturation could erase epigenetic landmarks on the
paternal genome, creating a challenge for its reestablishment on fertilization. Here, we show …

Actin’s presence in the nucleus is a subject that has ignited a lot of controversy in the past.
With our review, we attempt to reach out not only to the specialists but also to a broader …

Telomeres are obligatory chromosomal landmarks that demarcate the ends of linear chromosomes
to distinguish them from broken ends and can also serve to organize the genome. In …

Significant advances in genomics underscore the importance of targeted mutagenesis for
gene function analysis. Here we have developed a scheme for long-range targeted …

Changes in regulatory DNA contribute to phenotypic differences within and between taxa.
Comparative studies show that many transcription factor binding sites (TFBS) are conserved …

The beginnings of Drosophila as a model organism reach far back into the 1900s to Thomas
Hunt Morgan's first fly room. The success of this system for the study of genetics is closely …

Systematic mutational analysis is required for the comprehensive deciphering of gene
function. However, repeated targeting of a single locus is labor intensive and has not been a …

The rapid and synchronous divisions of large and transparent oocytes, eggs, and embryos
of marine species are exceptionally well suited for microscopic observation. Consequently, …