The evolutionarily conserved Crumbs protein complex is a key regulator of cell polarity and
cell shape in both invertebrates and vertebrates. The important role of this complex in normal …

Distributing junctional components around the cell periphery is key for epithelial tissue
morphogenesis and homeostasis. We discovered that positioning of dynamic microtubules …

Interphase microtubule organization is critical for cell function and tissue architecture. In
general, physical mechanisms are sufficient to drive microtubule organization in single cells, …

Epidermal growth factor receptor (EGFR) and adhesion protein E-cadherin are major regulators
of proliferation and differentiation in epithelial cells. Consistently, defects in both EGFR …

Salmonella Typhi activates the host DNA damage response through the typhoid toxin,
facilitating typhoid symptoms and chronic infections. Here we reveal a non-canonical DNA …

We highlight recent progress in understanding cadherin and integrin function in the model
organism Drosophila. New functions for these adhesion receptors continue to be discovered …

Epithelial tissues rely on the adhesion between participating cells to retain their integrity. The
transmembrane protein E-cadherin is the major protein that mediates homophilic adhesion …

Drosophila Stardust, a membrane-associated guanylate kinase (MAGUK), recruits the
transmembrane protein Crumbs and the cytoplasmic proteins DPATJ and DLin-7 into an apically …

The intracellular functions of classical cadherins are mediated through the direct binding of
two catenins: β-catenin and p120-catenin (also known as CTNND1 in vertebrates, and …

Drosophila Stardust (Sdt), a member of the MAGUK family of scaffolding proteins, is a
constituent of the evolutionarily conserved Crumbs-Stardust (Crb-Sdt) complex that controls …