Rac is a member of the Rho family of small GTPases, which act as molecular switches to
control a wide array of cellular functions. In particular, Rac signaling has been implicated in the …

Signaling via the Rho GTPases provides crucial regulation of numerous cell polarization
events, including apicobasal (AB) polarity, polarized cell migration, polarized cell division and …

The E3 ubiquitin ligase HUWE1, deregulated in carcinoma, has been implicated in tumor
formation. Here, we uncover a role for HUWE1 in cell migration and invasion through …

Although Rac and its activator Tiam1 are known to stimulate cell–cell adhesion, the mechanisms
regulating their activity in cell–cell junction formation are poorly understood. Here, we …

Oriented cell divisions are important for the formation of normal epithelial structures. Dlg1, a
tumour suppressor, is required for mitotic spindle orientation in Drosophila epithelia and …

Each cell within a polarized epithelial sheet must align and correctly position a wide range
of subcellular structures, including actin-based dynamic protrusions. Using in vivo inducible …

Metastasis is the leading cause of death for patients with cancer. Consequently it is
imperative that we improve our understanding of the molecular mechanisms that underlie …

Most research on southern Africa focuses on the total dependency of the region's states--Angola,
Botswana, Lesotho, Malawi, Mozambique, Swaziland, zambia and Zimbabwe--upon …

Oriented cell divisions are important for the formation of normal epithelial structures. Dlg1, a
tumour suppressor, is required for oriented cell division in Drosophila epithelia and chick …

Exposure to chronic stress is frequently accompanied by cognitive and affective disorders in
association with neurostructural adaptations. Chronic stress was previously shown to trigger …