User profiles for Natalie Jäger
Natalie JägerGerman Cancer Research Center and KiTZ, Heidelberg Verified email at kitz-heidelberg.de Cited by 25221 |
Signatures of mutational processes in human cancer
All cancers are caused by somatic mutations; however, understanding of the biological
processes generating these mutations is limited. The catalogue of somatic mutations from a …
processes generating these mutations is limited. The catalogue of somatic mutations from a …
Driver mutations in histone H3. 3 and chromatin remodelling genes in paediatric glioblastoma
Glioblastoma multiforme (GBM) is a lethal brain tumour in adults and children. However,
DNA copy number and gene expression signatures indicate differences between adult and …
DNA copy number and gene expression signatures indicate differences between adult and …
Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations
Medulloblastomas are the most common malignant brain tumours in children 1 . Identifying
and understanding the genetic events that drive these tumours is critical for the development …
and understanding the genetic events that drive these tumours is critical for the development …
[HTML][HTML] The whole-genome landscape of medulloblastoma subtypes
Current therapies for medulloblastoma, a highly malignant childhood brain tumour, impose
debilitating effects on the developing child, and highlight the need for molecularly targeted …
debilitating effects on the developing child, and highlight the need for molecularly targeted …
[HTML][HTML] Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations
Genomic rearrangements are thought to occur progressively during tumor development.
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
Recent findings, however, suggest an alternative mechanism, involving massive chromosome …
[HTML][HTML] Dissecting the genomic complexity underlying medulloblastoma
Medulloblastoma is an aggressively growing tumour, arising in the cerebellum or medulla/brain
stem. It is the most common malignant brain tumour in children, and shows tremendous …
stem. It is the most common malignant brain tumour in children, and shows tremendous …
[PDF][PDF] Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition
Smoothened (SMO) inhibitors recently entered clinical trials for sonic-hedgehog-driven
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(…
medulloblastoma (SHH-MB). Clinical response is highly variable. To understand the mechanism(…
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
Pilocytic astrocytoma, the most common childhood brain tumor 1 , is typically associated with
mitogen-activated protein kinase (MAPK) pathway alterations 2 . Surgically inaccessible …
mitogen-activated protein kinase (MAPK) pathway alterations 2 . Surgically inaccessible …
Enhancer hijacking activates GFI1 family oncogenes in medulloblastoma
…, L Sieber, H Seker-Cin, L Linke, F Kratochwil, N Jäger… - Nature, 2014 - nature.com
Medulloblastoma is a highly malignant paediatric brain tumour currently treated with a
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …
combination of surgery, radiation and chemotherapy, posing a considerable burden of toxicity to …
Quantitative comparison of genome-wide DNA methylation mapping technologies
DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …