User profiles for Natalie J. Prescott
 | Natalie J PrescottSenior Lecturer, Department of Medical and Molecular Genetics, King's College London Verified email at kcl.ac.uk Cited by 42580 |
Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease
Crohn’s disease and ulcerative colitis, the two common forms of inflammatory bowel disease
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
(IBD), affect over 2.5 million people of European ancestry, with rising prevalence in other …
Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease
…, NJ Prescott, CM Onnie, SA Fisher, J Marchini… - Nature …, 2008 - nature.com
Several risk factors for Crohn's disease have been identified in recent genome-wide association
studies. To advance gene discovery further, we combined data from three studies on …
studies. To advance gene discovery further, we combined data from three studies on …
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci
We undertook a meta-analysis of six Crohn's disease genome-wide association studies (GWAS)
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
comprising 6,333 affected individuals (cases) and 15,056 controls and followed up the …
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
…, FM De La Vega, J Briggs, S Günther, NJ Prescott… - Nature …, 2007 - nature.com
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were …
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47
Genome-wide association studies and candidate gene studies in ulcerative colitis have
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-…
Sequence variants in the autophagy gene IRGM and multiple other replicating loci contribute to Crohn's disease susceptibility
A genome-wide association scan in individuals with Crohn's disease by the Wellcome Trust
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …
Case Control Consortium detected strong association at four novel loci. We tested 37 SNPs …
Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease
Genetic association studies have identified 215 risk loci for inflammatory bowel disease 1 ,
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
2 , 3 , 4 , 5 , 6 , 7 , 8 , thereby uncovering fundamental aspects of its molecular biology. We …
Genetic determinants of ulcerative colitis include the ECM1 locus and five loci implicated in Crohn's disease
…, CA Anderson, R Gwilliam, S Bumpstead, NJ Prescott… - Nature …, 2008 - nature.com
We report results of a nonsynonymous SNP scan for ulcerative colitis and identify a previously
unknown susceptibility locus at ECM1. We also show that several risk loci are common to …
unknown susceptibility locus at ECM1. We also show that several risk loci are common to …
Sequence variants in the genes for the interleukin-23 receptor (IL23R) and its ligand (IL12B) confer protection against psoriasis
Psoriasis is an inflammatory skin disorder that is inherited as a multifactorial trait. Genetic
analyses have repeatedly identified a primary disease susceptibility locus lying within the …
analyses have repeatedly identified a primary disease susceptibility locus lying within the …
A nonsynonymous SNP in ATG16L1 predisposes to ileal Crohn's disease and is independent of CARD15 and IBD5
Background & Aims: A genome-wide association scan of nonsynonymous DNA polymorphisms
identified association of a threonine-to-alanine substitution (T300A) in the autophagy-…
identified association of a threonine-to-alanine substitution (T300A) in the autophagy-…