Pancreatic islet autoimmunity leading to type 1 diabetes could be triggered by viruses in
genetically susceptible individuals. Rotavirus (RV), the most common cause of childhood …

The tyrosine phosphatase IA-2 is a molecular target of pancreatic islet autoimmunity in type
1 diabetes. T-cell epitope peptides in autoantigens have potential diagnostic and therapeutic …

OBJECTIVE—Mucosal administration of insulin retards development of autoimmune diabetes
in the nonobese diabetic mouse model. We conducted a double-blind crossover study in …

In type 1 diabetes, insulin-producing β cells in the islets of the pancreas are destroyed by
autoreactive T cells. Rotavirus (RV) has been implicated in the pathogenesis of type 1 diabetes…

Activation of T cells requires recognition by T-cell receptors of specific peptides bound to
major histocompatibility complex (MHC) molecules on the surface of either antigen-presenting …

CD52, a glycophosphatidylinositol (GPI)-anchored glycoprotein, is released in a soluble
form following T cell activation and binds to the Siglec (sialic acid-binding Ig-like lectin)-10 …

Insulin-dependent or type 1 diabetes (T1D) is a paradigm for prevention of autoimmune
disease: Pancreatic β-cell autoantigens are defined, at-risk individuals can be identified before …

The incidence of type 1 diabetes globally has increased dramatically over the last 50 years.
Proposed environmental reasons for this increase mirror the modern lifestyle. Type 1 …

The ability to measure proliferation of autoantigen‐specific T cells is critical for the evaluation
of cellular immune function. Using a novel, sensitive, CFSE‐based assay, we were able to …

Type 1 diabetes in children is heralded by a preclinical phase defined by circulating
autoantibodies to pancreatic islet antigens. How islet autoimmunity is initiated and then progresses …