Immune checkpoint therapy has resulted in remarkable improvements in the outcome for
certain cancers. To broaden the clinical impact of checkpoint targeting, we devised a strategy …

Glioblastoma multiforme (GBM), the most aggressive brain cancer, recurs because glioblastoma
stem cells (GSCs) are resistant to all standard therapies. We showed that GSCs, but not …

Purpose: Natural killer (NK)-cell recognition and function against NK-resistant cancers remain
substantial barriers to the broad application of NK-cell immunotherapy. Potential solutions …

Virus-specific T cells have proven highly effective for the treatment of severe and drug-refractory
infections after hematopoietic stem cell transplant (HSCT). However, the efficacy of …

This study shows that a novel combination of MEK and AXL inhibitors effectively bypasses
EMT-mediated drug resistance in KRAS/p53-mutant non–small cell lung cancer by targeting …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Metastatic disease remains the leading cause of death due to cancer, yet the mechanism(s)
of metastasis and its timely detection remain to be elucidated. Neutrophil elastase (NE), a …

Both platelets and the liver play important roles in the processes of coagulation and innate
immunity. Platelet responses at the site of an injury are rapid; their immediate activation and …

Inferior vena cava filters (IVCFs) constructed with poly-p-dioxanone (PPDO) are promising
alternatives to metallic filters and their associated risks and complications. Incorporating high-…

The activity and safety of intraperitoneal paclitaxel in orthotopic PDX models of mucinous
appendiceal adenocarcinoma supports the evaluation of intraperitoneal paclitaxel in a …