Antiviral activities of type I interferons to SARS-CoV-2 infection

E Mantlo, N Bukreyeva, J Maruyama, S Paessler… - Antiviral research, 2020 - Elsevier
There is an urgent need to identify antivirals to curtail the COVID-19 pandemic. Herein, we
report the sensitivity of SARS-CoV-2 to recombinant human interferons α and β (IFNα/β). …

Catching and killing of airborne SARS-CoV-2 to control spread of COVID-19 by a heated air disinfection system

…, FH Cheema, WS Lawrence, N Bukreyeva… - Materials Today …, 2020 - Elsevier
Airborne transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
via air-conditioning systems poses a significant threat for the continued escalation of the …

Merimepodib, an IMPDH inhibitor, suppresses replication of Zika virus and other emerging viral pathogens

X Tong, J Smith, N Bukreyeva, T Koma, JT Manning… - Antiviral research, 2018 - Elsevier
Zika virus (ZIKV), a member of the Flaviviridae family, has recently been linked to abnormal
pregnancies, fetal death, microcephaly, and Guillain-Barré syndrome in humans. …

Fentanyl self-administration impacts brain immune responses in male Sprague-Dawley rats

…, SJ Stutz, RG Fox, N Bukreyeva… - Brain, behavior, and …, 2020 - Elsevier
Opioid use disorder (OUD) affects over two million in the United States and is an increasing
public health crisis. The abuse of fentanyl and the emergence of potent fentanyl derivatives …

Interferon γ expressed by a recombinant respiratory syncytial virus attenuates virus replication in mice without compromising immunogenicity

…, SS Whitehead, N Bukreyeva… - Proceedings of the …, 1999 - National Acad Sciences
Interferon γ (IFN-γ) has pleiotropic biological effects, including intrinsic antiviral activity as
well as stimulation and regulation of immune responses. An infectious recombinant human …

Adenoviral vector-based vaccine is fully protective against lethal Lassa fever challenge in Hartley guinea pigs

…, JT Manning, R Sattler, AV Seregin, N Bukreyeva… - Vaccine, 2019 - Elsevier
Lassa virus (LASV), the causative agent of Lassa fever (LF), was first identified in 1969. Since
then, outbreaks in the endemic countries of Nigeria, Liberia, and Sierra Leone occur on an …

[HTML][HTML] Zika virus infection elicits auto-antibodies to C1q

…, C Shan, PY Shi, DW Beasley, N Bukreyeva… - Scientific reports, 2018 - nature.com
Zika virus (ZIKV) causes mostly asymptomatic infection or mild febrile illness. However, with
an increasing number of patients, various clinical features such as microcephaly, Guillain-…

The IMPDH inhibitor merimepodib suppresses SARS-CoV-2 replication in vitro

N Bukreyeva, EK Mantlo, RA Sattler, C Huang… - BioRxiv, 2020 - biorxiv.org
The ongoing COVID-19 pandemic continues to pose a major public health burden around
the world. The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-…

[HTML][HTML] Virtual screen for repurposing of drugs for candidate influenza a M2 ion-channel inhibitors

…, J Prljic, V Veljkovic, E Mantlo, N Bukreyeva… - Frontiers in Cellular …, 2019 - frontiersin.org
Influenza A virus (IAV) matrix protein 2 (M2), an ion channel, is crucial for virus infection, and
therefore, an important anti-influenza drug target. Adamantanes, also known as M2 channel …

Lethal infection of Lassa virus isolated from a human clinical sample in outbred guinea pigs without adaptation

…, JT Manning, EJ Mateer, R Sattler, N Bukreyeva… - MSphere, 2019 - Am Soc Microbiol
Lassa virus (LASV), a member of the family Arenaviridae, is the causative agent of Lassa
fever. Lassa virus is endemic in West African countries, such as Nigeria, Guinea, Liberia, and …