The catalytic subunit of cAMP-dependent protein kinase has served as a prototype for the
protein kinase superfamily for many years while structures of the cAMP-bound regulatory …

Metagenomics projects based on shotgun sequencing of populations of micro-organisms
yield insight into protein families. We used sequence similarity clustering to explore proteins …

The eukaryotic protein kinase (ePK) domain mediates the majority of signaling and
coordination of complex events in eukaryotes. By contrast, most bacterial signaling is thought to …

Bayesian methods have been used quite extensively in recent years for solving small-area
estimation problems. Particularly effective in this regard has been the hierarchical or …

In contrast to T cell receptors, signal transducing cell surface membrane molecules involved
in the regulation of responses by cells of the innate immune system employ structures that …

The sequence and structure of a large body of proteins are becoming increasingly available.
It is desirable to explore mathematical tools for efficient extraction of information from such …

Background A substantial number of patients with rheumatoid arthritis have an inadequate
or unsustained response to tumor necrosis factor α (TNF-α) inhibitors. We conducted a …

Background Renal transplantation is the standard of care for patients with end-stage renal
disease. Although maintenance immunosuppression with calcineurin inhibitors yields …

Objectives This study conducted a prospective, single-arm, multicenter trial to evaluate the
safety and efficacy of ultrasound-facilitated, catheter-directed, low-dose fibrinolysis, using the …

NLRP3 is a key component of the macromolecular signaling complex called the inflammasome
that promotes caspase 1-dependent production of IL-1β. The adaptor ASC is necessary …