User profiles for Natasha D. Durham
 | Natasha D. DurhamUniversity of Massachusetts Medical School Verified email at umassmed.edu Cited by 525 |
[HTML][HTML] Conformational changes in the Ebola virus membrane fusion machine induced by pH, Ca2+, and receptor binding
The Ebola virus (EBOV) envelope glycoprotein (GP) is a membrane fusion machine required
for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by …
for virus entry into cells. Following endocytosis of EBOV, the GP1 domain is cleaved by …
Broadly neutralizing human antibodies against dengue virus identified by single B cell transcriptomics
Eliciting broadly neutralizing antibodies (bNAbs) against the four dengue virus serotypes (DENV1-4)
that are spreading into new territories is an important goal of vaccine design. To …
that are spreading into new territories is an important goal of vaccine design. To …
Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail
Human immunodeficiency virus type 1 (HIV-1) infection can spread efficiently from infected
to uninfected T cells through adhesive contacts called virological synapses (VSs). In this …
to uninfected T cells through adhesive contacts called virological synapses (VSs). In this …
P2X antagonists inhibit HIV-1 productive infection and inflammatory cytokines interleukin-10 (IL-10) and IL-1β in a human tonsil explant model
HIV-1 causes a persistent infection of the immune system that is associated with chronic
comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging …
comorbidities. The mechanisms that underlie this inflammation are poorly understood. Emerging …
P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection
Human immunodeficiency virus type 1 (HIV-1) infection is chronic and presently still incurable.
Antiretroviral drugs effectively suppress replication; however, persistent activation of …
Antiretroviral drugs effectively suppress replication; however, persistent activation of …
[HTML][HTML] Real-time analysis of individual Ebola virus glycoproteins reveals pre-fusion, entry-relevant conformational dynamics
The Ebola virus (EBOV) envelope glycoprotein (GP) mediates the fusion of the virion
membrane with the membrane of susceptible target cells during infection. While proteolytic …
membrane with the membrane of susceptible target cells during infection. While proteolytic …
HIV-1 cell-free and cell-to-cell infections are differentially regulated by distinct determinants in the Env gp41 cytoplasmic tail
The HIV-1 envelope (Env) glycoprotein mediates viral entry during both cell-free and cell-to-cell
infection of CD4 + T cells. The highly conserved long cytoplasmic tail (CT) of Env is …
infection of CD4 + T cells. The highly conserved long cytoplasmic tail (CT) of Env is …
Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells
…, C Zony, RA Alvarez, ND Durham… - The Journal of …, 2013 - academic.oup.com
The female genital epithelium plays a protective role against invading pathogens; however,
sexual transmission of human immunodeficiency virus type 1 (HIV-1) still occurs in healthy …
sexual transmission of human immunodeficiency virus type 1 (HIV-1) still occurs in healthy …
[HTML][HTML] A high throughput Cre–lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry
Enveloped virus entry occurs when viral and cellular membranes fuse releasing particle
contents into the target cell. Human immunodeficiency virus (HIV) entry occurs by cell-free virus …
contents into the target cell. Human immunodeficiency virus (HIV) entry occurs by cell-free virus …
[HTML][HTML] Enhanced FCGR2A and FCGR3A signaling by HIV viremic controller IgG
HIV-1 viremic controllers (VC) spontaneously control infection without antiretroviral treatment.
Several studies indicate that IgG Abs from VCs induce enhanced responses from immune …
Several studies indicate that IgG Abs from VCs induce enhanced responses from immune …