User profiles for Natasha Jansz
 | Natasha JanszSenior Research Officer, Mater Research, University of Queensland Verified email at mater.uq.edu.au Cited by 1155 |
Why weight? Modelling sample and observational level variability improves power in RNA-seq analyses
Variations in sample quality are frequently encountered in small RNA-sequencing
experiments, and pose a major challenge in a differential expression analysis. Removal of high …
experiments, and pose a major challenge in a differential expression analysis. Removal of high …
[HTML][HTML] Endogenous retroviruses in the origins and treatment of cancer
N Jansz, GJ Faulkner - Genome biology, 2021 - Springer
Endogenous retroviruses (ERVs) are emerging as promising therapeutic targets in cancer.
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …
As remnants of ancient retroviral infections, ERV-derived regulatory elements coordinate …
Comprehensive characterization of distinct states of human naive pluripotency generated by reprogramming
Recent reports on the characteristics of naive human pluripotent stem cells (hPSCs) obtained
using independent methods differ. Naive hPSCs have been mainly derived by conversion …
using independent methods differ. Naive hPSCs have been mainly derived by conversion …
Smchd1 regulates long-range chromatin interactions on the inactive X chromosome and at Hox clusters
N Jansz, A Keniry, M Trussart, H Bildsoe… - Nature structural & …, 2018 - nature.com
The regulation of higher-order chromatin structure is complex and dynamic, and a full
understanding of the suite of mechanisms governing this architecture is lacking. Here, we reveal …
understanding of the suite of mechanisms governing this architecture is lacking. Here, we reveal …
[PDF][PDF] Smchd1 targeting to the inactive X is dependent on the Xist-HnrnpK-PRC1 pathway
We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome
conformation. Smchd1 is critical for the structure of the inactive X chromosome and at …
conformation. Smchd1 is critical for the structure of the inactive X chromosome and at …
[HTML][HTML] Setdb1-mediated H3K9 methylation is enriched on the inactive X and plays a role in its epigenetic silencing
Background The presence of histone 3 lysine 9 (H3K9) methylation on the mouse inactive X
chromosome has been controversial over the last 15 years, and the functional role of H3K9 …
chromosome has been controversial over the last 15 years, and the functional role of H3K9 …
DNA methylation dynamics at transposable elements in mammals
N Jansz - Essays in Biochemistry, 2019 - portlandpress.com
Transposable elements dominate the mammalian genome, but their contribution to genetic
and epigenetic regulation has been largely overlooked. This was in part due to technical …
and epigenetic regulation has been largely overlooked. This was in part due to technical …
[PDF][PDF] Loss of p53 causes stochastic aberrant X-chromosome inactivation and female-specific neural tube defects
Neural tube defects (NTDs) are common birth defects in humans and show an unexplained
female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete …
female bias. Female mice lacking the tumor suppressor p53 display NTDs with incomplete …
The epigenetic regulator SMCHD1 in development and disease
It has very recently become clear that the epigenetic modifier SMCHD1 has a role in two
distinct disorders: facioscapulohumoral muscular dystrophy (FSHD) and Bosma arhinia and …
distinct disorders: facioscapulohumoral muscular dystrophy (FSHD) and Bosma arhinia and …
Somatic retrotransposition in the developing rhesus macaque brain
…, TJ Meyer, CE Layman, KA Nevonen, N Jansz… - Genome …, 2022 - genome.cshlp.org
The retrotransposon LINE-1 (L1) is central to the recent evolutionary history of the human
genome and continues to drive genetic diversity and germline pathogenesis. However, the …
genome and continues to drive genetic diversity and germline pathogenesis. However, the …